2012
Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application
Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application. Pharmacological Reviews 2012, 64: 520-539. PMID: 22544865, PMCID: PMC3400832, DOI: 10.1124/pr.111.005538.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRetinoic acid signalingSuperfamily of enzymesCellular defense mechanismsALDH isozymesCellular homeostasisMechanism of actionAcid signalingCorneal crystallinsSubstrate specificityIsozyme-selective inhibitorsALDH enzymesToxicological functionsKey enzymeHuman ALDHHuman diseasesHuman cancersDefense mechanismsPharmacological inhibitionToxicological roleReactive aldehydesALDH inhibitorsIsozymesEnzymeUltraviolet radiation-induced damagePivotal role
2008
Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle
Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW. Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle. Molecular Pharmacology 2008, 75: 555-567. PMID: 19047483, PMCID: PMC2684908, DOI: 10.1124/mol.108.051888.Peer-Reviewed Original ResearchConceptsMitochondrial importCryptic targeting signalMitochondrial-targeting signalSignal recognition particleInner mitochondrial membraneDifferent substrate specificitiesMouse linesCYP1A1 proteinTargeting signalsRecognition particleCYP1A1 enzymeSubstrate specificityMitochondrial membraneEndoplasmic reticulumBaP toxicityPhysiological functionsTerminal processingProteinCytosolic peptidasesProof of principleMutationsEnzymeInducer propertiesCYP1B1 mRNAMicrosomal CYP1A1