2021
Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia
Gao X, Gao M, Gorecka J, Langford J, Liu J, Luo J, Taniguchi R, Matsubara Y, Liu H, Guo L, Gu Y, Qyang Y, Dardik A. Human-Induced Pluripotent Stem-Cell-Derived Smooth Muscle Cells Increase Angiogenesis to Treat Hindlimb Ischemia. Cells 2021, 10: 792. PMID: 33918299, PMCID: PMC8066461, DOI: 10.3390/cells10040792.Peer-Reviewed Original ResearchConceptsLimb-threatening ischemiaSmooth muscle cellsHindlimb ischemiaFunctional outcomeChronic limb-threatening ischemiaMuscle cellsVascular endothelial growth factor (VEGF) expressionM2-type macrophagesMurine hindlimb ischemia modelNumber of macrophagesGrowth factor expressionLaser Doppler imagingStem cell sourceHindlimb ischemia modelStem cellsConsiderable ethical issuesTranslatable therapyIschemic limbsRenewable stem cell sourcesIschemia modelCapillary densityBlood flowIschemiaNovel treatmentsNude mice
2004
Myeloproliferative Disease in Mice with Reduced Presenilin Gene Dosage: Effect of γ-Secretase Blockage †
Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Myeloproliferative Disease in Mice with Reduced Presenilin Gene Dosage: Effect of γ-Secretase Blockage †. Biochemistry 2004, 43: 5352-5359. PMID: 15122901, DOI: 10.1021/bi049826u.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesCell LineageColony-Forming Units AssayEndopeptidasesFemaleGene DosageGranulocytesHematopoiesisLeukocyte CountMacrophagesMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMyeloproliferative DisordersPresenilin-1Presenilin-2Protease InhibitorsConceptsGamma-secretase activityDisease interventionWild-type splenocytesAlzheimer's disease interventionsAmyloid precursor proteinGranulocyte-macrophage colony-forming unitsGamma-secretase inhibitorsGamma-secretase cleavageGranulocyte infiltrationPotential therapyMyeloproliferative diseaseB lymphocytesBone marrowPS inactivationHematopoietic stem cellsColony-forming unitsGranulocytic cells