2015
Development of Small Diameter Nanofiber Tissue Engineered Arterial Grafts
Kurobe H, Maxfield MW, Tara S, Rocco KA, Bagi PS, Yi T, Udelsman B, Zhuang ZW, Cleary M, Iwakiri Y, Breuer CK, Shinoka T. Development of Small Diameter Nanofiber Tissue Engineered Arterial Grafts. PLOS ONE 2015, 10: e0120328. PMID: 25830942, PMCID: PMC4382213, DOI: 10.1371/journal.pone.0120328.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsSmall-diameter arteriesSynthetic graftsDiameter arteriesSurvival of miceLarge-sized arteriesF4/80-positive macrophagesInner luminal diameterMatrix metalloproteinases 2Smooth muscle actinAneurysmal dilatationGraft stenosisSurgical repairPatency ratesSham groupArterial graftsSized arteriesVascular diseaseSham operationBg miceLuminal diameterDoppler ultrasoundHistologic analysisInterposition conduitsMuscle actin
2013
Reticulon 4B (Nogo‐B) facilitates hepatocyte proliferation and liver regeneration in mice
Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y. Reticulon 4B (Nogo‐B) facilitates hepatocyte proliferation and liver regeneration in mice. Hepatology 2013, 57: 1992-2003. PMID: 23299899, PMCID: PMC3628958, DOI: 10.1002/hep.26235.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationEpidermal Growth FactorHepatectomyHepatocyte Growth FactorHepatocytesInterleukin-6LiverLiver RegenerationMaleMiceMice, Inbred C57BLMice, KnockoutModels, AnimalMyelin ProteinsNogo ProteinsSignal TransductionSTAT3 Transcription FactorTime FactorsTransforming Growth Factor betaConceptsHepatocyte growth factorRole of NogoInterleukin-6Hepatocyte proliferationLiver regenerationEpidermal growth factorReticulon 4BTGF-β1Growth factorKi67 labeling indexB knockout miceHepatic stellate cellsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionIL-6/signal transducerGrowth factor βTime-dependent mannerRemnant liverKO miceLiver fibrosisPolymerase chain reactionInhibitor of DNAStellate cellsKnockout miceLabeling index
2003
Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats
Tsai MH, Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Gastroenterology 2003, 125: 1452-1461. PMID: 14598261, DOI: 10.1016/j.gastro.2003.07.014.Peer-Reviewed Original ResearchConceptsPartial portal vein ligationSuperior mesenteric arterySMA vascular resistancePortal hypertensive ratsRAL ratsMesenteric vasoconstrictionPortal pressureVascular resistanceArterial pressureHypertensive ratsMesenteric arteryNitric oxide synthase activityNitric oxide synthase enzyme activitySMA blood flowMean arterial pressurePerfusion pressure changesPortal vein ligationENOS protein expressionSham-operated ratsOxide synthase activityMonomethyl-L-arginineNitric oxide overproductionEffects of vasoconstrictionRenal artery ligationENOS catalytic activity