Yang Yang, PhD
Associate Professor of Obstetrics, Gynecology and Reproductive SciencesDownloadHi-Res Photo
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Associate Professor of Obstetrics, Gynecology and Reproductive Sciences
Biography
Ph.D., Microbiology, Nankai University, China.
Postdoctoral training, Tumor Biology, Yale University.
Last Updated on May 18, 2025.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- PhD
- Nankai University (2009)
Research
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Overview
Tumor initiation; Chemoresistance
Medical Research Interests
Ovarian Neoplasms
ORCID
0000-0002-0522-9053
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yang Yang's published research.
Publications Timeline
A big-picture view of Yang Yang's research output by year.
Research Interests
Research topics Yang Yang is interested in exploring.
Alessandro Santin, MD
Stefania Bellone, PhD
Blair McNamara, MD
Tobias Hartwich, PhD
Levent Mutlu
Former YSMCem Demirkiran, MD
68Publications
2,650Citations
Ovarian Neoplasms
Publications
2026
Rates of hypertensive disorders of pregnancy among patients with placenta accreta spectrum
Sinnott C, Alshowaikh K, Culhane J, Lundsberg L, Kolesnyk V, Partridge C, Giuliano S, Yang-Hartwich Y, Abdel-Razeq S, Grechukhina O. Rates of hypertensive disorders of pregnancy among patients with placenta accreta spectrum. American Journal Of Obstetrics & Gynecology MFM 2026, 8: 101919. PMID: 42091294, DOI: 10.1016/j.ajogmf.2026.101919.Commentaries, Editorials and LettersGRP78 Selective Inhibitors From a Direct‐to‐Biology Strategy
Zhu X, Trindl C, Li Q, Ye H, Alexander L, Huang D, Wei Y, Trieu V, Stansfield B, Ooi A, Yang‐Hartwich Y, Zhang D, Chapman E. GRP78 Selective Inhibitors From a Direct‐to‐Biology Strategy. Angewandte Chemie International Edition 2026, 65: e23960. PMID: 42023476, DOI: 10.1002/anie.202523960.Peer-Reviewed Original ResearchGRP78 Selective Inhibitors From a Direct‐to‐Biology Strategy
Zhu X, Trindl C, Li Q, Ye H, Alexander L, Huang D, Wei Y, Trieu V, Stansfield B, Ooi A, Yang‐Hartwich Y, Zhang D, Chapman E. GRP78 Selective Inhibitors From a Direct‐to‐Biology Strategy. Angewandte Chemie 2026, 138 DOI: 10.1002/ange.202523960.Peer-Reviewed Original ResearchIdentification of Maternal Serum Longitudinal Signatures Through Profiling of 96 Cytokines
Kolesnyk V, Sinnott C, Hartwich T, Gandhi F, Culhane J, Lundsberg L, Abdel-Razeq S, Mansolf M, Novo S, Grechukhina O, Yang-Hartwich Y. Identification of Maternal Serum Longitudinal Signatures Through Profiling of 96 Cytokines. Life 2026, 16: 710. PMID: 42195265, PMCID: PMC13208128, DOI: 10.3390/life16050710.Peer-Reviewed Original ResearchIntegrated mutational landscape analysis of endometrial stromal sarcoma
Hartwich T, Choi S, Hwang A, Bellone S, Palmieri L, Seo H, Kim T, Hong J, Krakstad C, Trovik J, Stefansson I, Haugland H, Greenman M, Ettorre V, Ottum S, Demirkiran C, Yang-Hartwich Y, Buza N, Hui P, Lopez S, Cormio G, Ramunno M, Zito A, Perrone E, Fagotti A, Fanfani F, Santoro A, Ravaggi A, Bignotti E, Odicino F, Ardighieri L, Ratner E, Angioli R, Perrone G, Luvero D, Conca B, Choi J, Schlessinger J, Santin A. Integrated mutational landscape analysis of endometrial stromal sarcoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2531105123. PMID: 41591910, PMCID: PMC12867622, DOI: 10.1073/pnas.2531105123.Peer-Reviewed Original ResearchCitationsPrenatal overdiagnosis of placenta accreta spectrum: associated factors and perinatal outcomes
Grechukhina O, Sinnott C, Alshowaikh K, Culhane J, Lundsberg L, Partridge C, Yang-Hartwich Y, Bahtiyar M, Abdel-Razeq S. Prenatal overdiagnosis of placenta accreta spectrum: associated factors and perinatal outcomes. American Journal Of Obstetrics & Gynecology MFM 2026, 8: 101850. PMID: 41513313, DOI: 10.1016/j.ajogmf.2025.101850.Commentaries, Editorials and Letters
2025
Antibody Generation Using Cancer‐Derived Small Extracellular Vesicles (sEVs): A Platform for Targeted Cancer Therapy and Potential Personalized Applications
Firouzi M, Kang C, Ren X, Jung W, Abushukair H, Hartwich T, Ramesh R, Yoon J, Yang‐Hartwich Y, Oh T, Kim D. Antibody Generation Using Cancer‐Derived Small Extracellular Vesicles (sEVs): A Platform for Targeted Cancer Therapy and Potential Personalized Applications. Small 2025, 22: e06918. PMID: 41311345, DOI: 10.1002/smll.202506918.Peer-Reviewed Original ResearchAltmetricIDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers
Zhang X, Xiao Q, Zeng L, Hashmi F, Sato K, Hartwich T, Mansolf M, Yang-Hartwich Y, Su X. IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers. Nature Chemical Biology 2025, 22: 379-391. PMID: 41023404, PMCID: PMC12825998, DOI: 10.1038/s41589-025-02031-x.Peer-Reviewed Original ResearchCitationsAltmetricPreclinical Efficacy of the Estrogen Receptor Degrader Fulvestrant in Combination with RAF/MEK Clamp Avutometinib and FAK Inhibitor in a Low-Grade Serous Ovarian Cancer Animal Model with Acquired Resistance to Chemotherapy and Aromatase Inhibitor
Demirkiran C, Bellone S, Ettorre V, Mansolf M, Hartwich T, McNamara B, Greenman M, Yang-Hartwich Y, Ratner E, Santin N, Sethi N, Palmieri L, Coma S, Pachter J, Ottum S, Santin A. Preclinical Efficacy of the Estrogen Receptor Degrader Fulvestrant in Combination with RAF/MEK Clamp Avutometinib and FAK Inhibitor in a Low-Grade Serous Ovarian Cancer Animal Model with Acquired Resistance to Chemotherapy and Aromatase Inhibitor. International Journal Of Molecular Sciences 2025, 26: 8924. PMID: 41009492, PMCID: PMC12469703, DOI: 10.3390/ijms26188924.Peer-Reviewed Original ResearchCitationsMeSH KeywordsTET3 is a common epigenetic immunomodulator of pathogenic macrophages
Liu B, Dai Y, Wang Z, Song J, Du Y, Lv H, Bellone S, Yang Y, Kennedy A, Zhang S, Venkatachalapathy M, Surovtseva Y, Wang P, Carmichael G, Taylor H, Zhang X, Li D, Huang Y. TET3 is a common epigenetic immunomodulator of pathogenic macrophages. Journal Of Clinical Investigation 2025, 135: e194879. PMID: 40794443, PMCID: PMC12578387, DOI: 10.1172/jci194879.Peer-Reviewed Original ResearchThis study investigates the role of TET3 in promoting pathogenic macrophages across chronic inflammatory diseases, and shows that selectively eliminating TET3-overexpressing macrophages (“Toe-Macs”) can mitigate disease progression in conditions like MASH, NSCLC, and endometriosis.
Academic Achievements & Community Involvement
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Honors
honor Department of Defense Ovarian Cancer Academy Award — Early-Career Investigator
08/01/2015National AwardDepartment of DefenseDetailsUnited Stateshonor Marsha Rivkin Ovarian Cancer Research Bridge Fund Award
06/01/2015International AwardMarsha Rivkin Ovarian Cancer Research CenterDetailsUnited Stateshonor American Association of Cancer Research Women in Cancer Research Scholar Award
04/14/2014International AwardAmerican Association of Cancer ResearchDetailsUnited Stateshonor Ovarian Cancer Research Ann Schreiber Program of Excellence Award
03/01/2014International AwardOvarian Cancer Research FundDetailsUnited States
News & Links
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Media
News
- September 29, 2025
New Toolset by Yale Researchers Boosts Efficacy of CAR-T Cells Targeting Blood and Solid Cancers
- April 15, 2024
Genetic Analysis of Rare, Often Deadly Cervical Cancer Uncovers Potential Treatments
- January 19, 2024Source: Yale Daily News
Yale scientists look to hearing loss to detect Alzheimer’s early
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LSOG 205a
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Farnam Memorial Building (330 Cedar)
330 Cedar Street
New Haven, CT 06510