2017
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response
Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2017, 2: e90780. PMID: 28289714, PMCID: PMC5333973, DOI: 10.1172/jci.insight.90780.Peer-Reviewed Original ResearchConceptsLiver injuryInflammatory responseBile acid-induced liver injuryCholestatic liver injuryInflammatory liver injuryProinflammatory cytokine expressionCholestatic liver diseaseBile duct ligationVivo mouse modelHepatic infiltrationInflammatory injurySerum aminotransferasesLiver diseaseCholestatic patientsCytokine expressionChemokine inductionPathophysiologic concentrationsNeutrophil chemotaxisDuct ligationPathophysiologic levelsMouse modelNew therapiesInnate immunityInjuryPeriportal areas
2008
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 20446-20451. PMID: 19074283, PMCID: PMC2629334, DOI: 10.1073/pnas.0810372105.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Toll-like receptorsType II IFNImmune responseNucleic acid-sensing Toll-like receptorsReceptor 3Innate antiviral immune responseAntiviral innate immune responseTLR3-deficient miceType I IFN responseAntiviral immune responseAntiviral innate immunityInnate immune responseI IFN responseInnate antiviral immunityType II interferonAcute myocarditisVirus infectionAntiviral immunityI IFNMouse resistanceInnate immunityTypes of virusesIFN responseIFN
2007
Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation
Ouyang X, Negishi H, Takeda R, Fujita Y, Taniguchi T, Honda K. Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation. Biochemical And Biophysical Research Communications 2007, 354: 1045-1051. PMID: 17275788, DOI: 10.1016/j.bbrc.2007.01.090.Peer-Reviewed Original ResearchConceptsToll-like receptorsInterferon regulatory factor 5TLR synergyTRIF pathwayImmune systemMultiple Toll-like receptorsTranscription factor interferon regulatory factor 5Regulatory factor 5Agonist combinationsImmune cellsMyD88 adaptorInnate immunityIRF5 activationTRIF adaptorMyD88Synergistic inductionActivationFactor 5Target genesCross talkCellsAgonistsTRIFPathwayImmunity