2016
Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects
Chowdhury GM, Zhang J, Thomas M, Banasr M, Ma X, Pittman B, Bristow L, Schaeffer E, Duman RS, Rothman DL, Behar KL, Sanacora G. Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects. Molecular Psychiatry 2016, 22: 120-126. PMID: 27067013, PMCID: PMC5345902, DOI: 10.1038/mp.2016.34.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsBrainGamma-Aminobutyric AcidGlutamic AcidGlutamineKetamineMagnetic Resonance SpectroscopyMalePhenolsPiperidinesPrefrontal CortexRatsRats, Sprague-DawleyScopolamineConceptsAntidepressant-like efficacyAntidepressant actionRo 25Glutamate cyclingAntidepressant-like effectsRapid antidepressant effectsClear dose-dependent effectRapid antidepressant actionsDose-dependent effectEffects of scopolamineRapid transient riseAntidepressant effectsAntidepressant propertiesIntravenous infusionSingle doseAntidepressant activityIntraperitoneal injectionClinical trialsDrug injectionAwake ratsNovel agentsRat PFCRodent modelsRapid onsetUnique drug
2013
Metabolic products of [2‐13C]ethanol in the rat brain after chronic ethanol exposure
Wang J, Du H, Ma X, Pittman B, Castracane L, Li T, Behar KL, Mason GF. Metabolic products of [2‐13C]ethanol in the rat brain after chronic ethanol exposure. Journal Of Neurochemistry 2013, 127: 353-364. PMID: 24033360, PMCID: PMC6145094, DOI: 10.1111/jnc.12405.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureEthanol exposureCerebral oxidationAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsEthanol-derived acetateEthanol-exposed ratsSprague-Dawley ratsBrain energy metabolismLateral tail veinEthanol-naïve ratsLong-term adaptationCerebral uptakeIntravenous infusionControl ratsRat brainTail veinChronic exposureRatsRoom airIngested ethanolGABABrainKey neurochemicalsEnergy metabolismOxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure
Wang J, Du H, Jiang L, Ma X, de Graaf RA, Behar KL, Mason GF. Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 14444-14449. PMID: 23940368, PMCID: PMC3761635, DOI: 10.1073/pnas.1306011110.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol-Related DisordersAnimalsBrainEthanolGlutamic AcidGlycineMagnetic Resonance SpectroscopyMaleOxidation-ReductionRatsRats, Sprague-DawleyConceptsChronic ethanol exposureEthanol-naïve ratsAlcohol exposureEthanol exposureAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsMin/Chronic alcohol exposureCerebral glucose metabolismAcute alcohol exposureEthanol-treated ratsSprague-Dawley ratsCortical astrogliaOverall oxidative metabolismRat brainGlucose metabolismRatsRoom airLiving brainAstrogliaSubcortical tissueOxidative metabolismNeuronsBrainOxidative damage
2010
Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine
Wang J, Jiang L, Jiang Y, Ma X, Chowdhury GM, Mason GF. Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine. Journal Of Neurochemistry 2010, 113: 1447-1458. PMID: 20345764, PMCID: PMC2903655, DOI: 10.1111/j.1471-4159.2010.06684.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsAspartic AcidBrainIsotopesMagnetic Resonance SpectroscopyMaleModels, BiologicalNicotineNicotinic AgonistsPlasmaRatsRats, Sprague-DawleyTime FactorsWakefulnessConceptsRat brainN-acetylaspartateAcute nicotine treatmentBrain glucose oxidationAmino acid neurotransmittersInfluence of nicotineConcentration of glutamateRegional metabolite levelsAwake rat brainRelated neurochemicalsNicotine treatmentInhibitory neurotransmissionAcute effectsOlfactory bulbOccipital cortexNeurotransmitter cyclingGABA synthesisNicotineStriatumBrainMetabolite levelsWidespread drugGABACortexPotential interplay