2024
Improving diagnostic yield of pancreatic serous cystadenoma with cyst fluid ancillary testing, adjunct immunohistochemistry, and additional fine‐needle biopsy sampling
Wang X, Zhang X, Hui P, Cai G. Improving diagnostic yield of pancreatic serous cystadenoma with cyst fluid ancillary testing, adjunct immunohistochemistry, and additional fine‐needle biopsy sampling. Cancer Cytopathology 2024, 132: 425-434. PMID: 38450993, DOI: 10.1002/cncy.22808.Peer-Reviewed Original ResearchDiagnosis of serous cystadenomaFine-needle biopsyFine-needle aspirationCyst fluid carcinoembryonic antigenPancreatic serous cystadenomaSerous cystadenomaAncillary testsCEA levelsCytological diagnosisFine-needle aspiration cell blocksFine-needle aspiration diagnosisFine-needle aspiration casesCyst fluid CEA levelsSerous cystadenoma casesFluid carcinoembryonic antigenLow CEA levelFine-needle biopsy samplingKRAS mutation analysisWild-type KRASConcurrent fine-needle aspirationImprove diagnostic yieldInhibin immunostainingAtypical cellsCytology casesDiagnostic yield
2023
The Milan System for Reporting Salivary Gland Cytopathology and Updates
Wang X, Wang H. The Milan System for Reporting Salivary Gland Cytopathology and Updates. J Clin Transl Pathol. 2023;3(3):126-133. doi: 10.14218/JCTP.2023.00011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification
Wang X, Abi‐Raad R, Tang H, Cai G. Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification. Cancer Cytopathology 2022, 130: 974-982. PMID: 35876606, DOI: 10.1002/cncy.22630.Peer-Reviewed Original ResearchConceptsGastrointestinal stromal tumorsKi-67 indexHigh mitotic rateLow mitotic rateCell block sectionsMitotic rateMitotic countRisk stratificationStromal tumorsSurgical specimensRisk of GISTCytology specimensMean Ki-67 indexPotential predictive valueBlock sectionsFine-needle aspiration specimensKi-67 immunostainLMR groupSurgical resectionDistal esophagusTumor sizeSpindle cellsGIST casesFNA specimensPredictive valueCOVID-19 & differential effects in twins: Insights from Placenta Pathology
Moriarty K, Yu M, Hussain N, Zgutka K, Sanders MM, Harigopal M, Wang J, Wang X, Hui P, Liu C, Sink D, Shields A. COVID-19 & differential effects in twins: Insights from Placenta Pathology. Placenta 2022, 124: 62-66. PMID: 35640456, PMCID: PMC9121647, DOI: 10.1016/j.placenta.2022.05.014.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Perinatal lossCOVID-19Adverse pregnancy outcomesMaternal-fetal interfaceTime of infectionDifferential effectsPregnancy outcomesPremature deliveryFetal interfaceGestational agePlacenta pathologyTwin pregnanciesMembranous expressionFemale fetusesFetal sexViral detection methodsViral receptorsFemale twinsTissue resultsPregnancyPlacentaTask ForceSuccumbedFetusesHepatocellular adenoma: Where are we now?
Wang X, Zhang X. Hepatocellular adenoma: Where are we now? World Journal Of Gastroenterology 2022, 28: 1384-1393. PMID: 35582672, PMCID: PMC9048476, DOI: 10.3748/wjg.v28.i14.1384.Peer-Reviewed Original ResearchConceptsHepatocellular adenomaOral contraceptive useUnderlying molecular signaturesClinical managementHepatocellular neoplasmsContraceptive useHigh riskMalignant transformationYoung womenMolecular featuresMolecular signaturesSubtypesMolecular studiesClassification systemComplicationsHemorrhageAdenomasNeoplasmsNeuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature
Wang X, Habet V, Aboian M, Leelatian N, McGuone D, Morotti R, Kandil S, Darbinyan A. Neuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature. Journal Of Neuropathology & Experimental Neurology 2022, 81: 296-298. PMID: 35139536, DOI: 10.1093/jnen/nlab137.Peer-Reviewed Original Research
2021
Somatic Mutation of BAP1 Can Lead to Expression Loss in Non-Small Cell Lung Carcinoma: Next Generation Sequencing and IHC Analysis in A Large Single Institute Cohort
Sun T, Wang X, Wang M, Minerowicz C, Sanchez H, Laskin W, Cohen P, Zhong M. Somatic Mutation of BAP1 Can Lead to Expression Loss in Non-Small Cell Lung Carcinoma: Next Generation Sequencing and IHC Analysis in A Large Single Institute Cohort. International Journal Of Surgical Pathology 2021, 30: 512-519. PMID: 34970936, DOI: 10.1177/10668969211070179.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaLung carcinomaCell carcinomaSomatic mutationsClear cell renal cell carcinomaExpression lossCell renal cell carcinomaSquamous cell carcinomaNext-generation sequencingGenetic alterationsRenal cell carcinomaBAP1 protein expressionProtein expression statusStudy cohortNSCLC casesNSCLC tumorsLoss of expressionNeural tumorsAdditional genetic alterationsCommon findingIHC analysisNSCLC carcinogenesisIRB approvalMelanocytic tumors
2019
PDGF Modulates BMP2-Induced Osteogenesis in Periosteal Progenitor Cells.
Wang X, Matthews BG, Yu J, Novak S, Grcevic D, Sanjay A, Kalajzic I. PDGF Modulates BMP2-Induced Osteogenesis in Periosteal Progenitor Cells. JBMR Plus 2019, 3: e10127. PMID: 31131345, PMCID: PMC6524680, DOI: 10.1002/jbm4.10127.Peer-Reviewed Original ResearchSkeletal phenotype of the neuropeptide Y knockout mouse.
Wee NKY, Sinder BP, Novak S, Wang X, Stoddard C, Matthews BG, Kalajzic I. Skeletal phenotype of the neuropeptide Y knockout mouse. Neuropeptides 2019, 73: 78-88. PMID: 30522780, PMCID: PMC6326877, DOI: 10.1016/j.npep.2018.11.009.Peer-Reviewed Original ResearchA PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing.
Doherty L, Yu J, Wang X, Hankenson KD, Kalajzic I, Sanjay A. A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing. PloS One 2019, 14: e0223846. PMID: 31665177, PMCID: PMC6821073, DOI: 10.1371/journal.pone.0223846.Peer-Reviewed Original Research
2017
Splenomegaly, myeloid lineage expansion and increased osteoclastogenesis in osteogenesis imperfecta murine.
Matthews BG, Roeder E, Wang X, Aguila HL, Lee SK, Grcevic D, Kalajzic I. Splenomegaly, myeloid lineage expansion and increased osteoclastogenesis in osteogenesis imperfecta murine. Bone 2017, 103: 1-11. PMID: 28600151, PMCID: PMC5764163, DOI: 10.1016/j.bone.2017.06.004.Peer-Reviewed Original Research
2016
Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood.
Matic I, Matthews BG, Wang X, Dyment NA, Worthley DL, Rowe DW, Grcevic D, Kalajzic I. Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood. Stem Cells (Dayton, Ohio) 2016, 34: 2930-2942. PMID: 27507737, PMCID: PMC5450652, DOI: 10.1002/stem.2474.Peer-Reviewed Original Research
2015
Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy.
Mittal P, St Rose MC, Wang X, Ryan JM, Wasser JS, Vella AT, Adler AJ. Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy. Journal Of Immunology (Baltimore, Md. : 1950) 2015, 195: 5816-26. PMID: 26561553, PMCID: PMC4670784, DOI: 10.4049/jimmunol.1502032.Peer-Reviewed Original Research