2023
Accelerated aging mediates the associations of unhealthy lifestyles with cardiovascular disease, cancer, and mortality
Li X, Cao X, Zhang J, Fu J, Mohedaner M, Danzengzhuoga, Sun X, Yang G, Yang Z, Kuo C, Chen X, Cohen A, Liu Z. Accelerated aging mediates the associations of unhealthy lifestyles with cardiovascular disease, cancer, and mortality. Journal Of The American Geriatrics Society 2023, 72: 181-193. PMID: 37789775, PMCID: PMC11078652, DOI: 10.1111/jgs.18611.Peer-Reviewed Original ResearchIncident cardiovascular diseaseCardiovascular diseaseUnhealthy lifestyleCause mortalityIncident cancerUK BiobankCox proportional hazards modelUnhealthy lifestyle scoreAssociation of lifestyleNutrition Examination SurveyUS National HealthProportional hazards modelAdverse health outcomesAge accelerationBiological age accelerationLifestyle interventionCVD mortalityLifestyle scoreExamination SurveyCancer mortalityBlood biomarkersMorbidity riskNational HealthMediation proportionHazards model
2022
Association of Unhealthy Lifestyle and Childhood Adversity With Acceleration of Aging Among UK Biobank Participants
Yang G, Cao X, Li X, Zhang J, Ma C, Zhang N, Lu Q, Crimmins EM, Gill TM, Chen X, Liu Z. Association of Unhealthy Lifestyle and Childhood Adversity With Acceleration of Aging Among UK Biobank Participants. JAMA Network Open 2022, 5: e2230690. PMID: 36066889, PMCID: PMC9449787, DOI: 10.1001/jamanetworkopen.2022.30690.Peer-Reviewed Original ResearchConceptsOnline mental health surveyMental Health SurveyUnhealthy lifestyleChildhood adversityHealth SurveyAge accelerationChildhood adversity scoreUnhealthy lifestyle scoreRetrospective cohort studyRetrospective cohort analysisBody mass indexUK Biobank participantsCohort studyLifestyle interventionLifestyle scoreSmoking statusMass indexChronic diseasesCohort analysisMAIN OUTCOMEPhysical activityAlcohol consumptionAdversity scoreFormal mediation analysisBiobank participants