High Spatial Resolution Observation of Single-Molecule Dynamics in Living Cell Membranes
Edel J, Wu M, Baird B, Craighead H. High Spatial Resolution Observation of Single-Molecule Dynamics in Living Cell Membranes. Biophysical Journal 2005, 88: l43-l45. PMID: 15821167, PMCID: PMC1305672, DOI: 10.1529/biophysj.105.061937.Peer-Reviewed Original ResearchConceptsZero-mode waveguidesHigh spatial resolution observationsSpatial resolution observationsCell membraneSingle-molecule dynamicsOptical confinementBiological membrane functionResolution observationsCell membrane componentsFluorescent excitationCellular organellesCytosolic poolCellular membranesMembrane componentsSingle moleculesMembrane functionLipid diffusionBiological membranesRat basophilic leukemia cellsLipid bilayersConfocal microscopyConfinementBasophilic leukemia cellsIndividual moleculesEssential building blocks