2017
FFAR2‐FFAR3 receptor heteromerization modulates short‐chain fatty acid sensing
Ang Z, Xiong D, Wu M, Ding JL. FFAR2‐FFAR3 receptor heteromerization modulates short‐chain fatty acid sensing. The FASEB Journal 2017, 32: 289-303. PMID: 28883043, PMCID: PMC5731126, DOI: 10.1096/fj.201700252rr.Peer-Reviewed Original ResearchMeSH KeywordsBeta-Arrestin 2Calcium SignalingColitisCyclic AMPFatty Acids, VolatileFluorescence Resonance Energy TransferHEK293 CellsHumansMacrophagesObesityP38 Mitogen-Activated Protein KinasesPhosphorylationProtein MultimerizationReceptors, Cell SurfaceReceptors, G-Protein-CoupledRecombinant ProteinsConceptsShort-chain fatty acidsBimolecular fluorescence complementationReceptor heteromerizationGut microbiota-derived short-chain fatty acidsMicrobiota-derived short-chain fatty acidsFluorescence complementationFluorescence resonance energy transferHeterologous expressionFree fatty acid receptor 2Mammalian receptorsFatty acidsFatty acid sensingProximity ligationDrug targetsΒ-arrestinHEK293 cellsPrimary human monocytesResonance energy transferNovel pathwayCytosolic CaP38 phosphorylationHeteromersInflammatory monocytesReceptor 2Receptor heteromers
2005
Lipid segregation and IgE receptor signaling: A decade of progress
Holowka D, Gosse J, Hammond A, Han X, Sengupta P, Smith N, Wagenknecht-Wiesner A, Wu M, Young R, Baird B. Lipid segregation and IgE receptor signaling: A decade of progress. Biochimica Et Biophysica Acta 2005, 1746: 252-259. PMID: 16054713, DOI: 10.1016/j.bbamcr.2005.06.007.Peer-Reviewed Original ResearchConceptsLipid raftsReceptor phosphorylationSrc family kinase LynTransmembrane tyrosine phosphataseLipid segregationPlasma membrane resultsIgE receptor signalingCell surface receptorsActive LynKinase LynTyrosine phosphataseCytoskeletal interactionsSignal transductionRaft environmentMembrane skeletonDisordered regionsReceptor signalingSurface receptorsSegregation of liquidIgE receptorMembrane structureLynPhosphorylationMembrane resultsComplex role
2004
Visualization of plasma membrane compartmentalization with patterned lipid bilayers
Wu M, Holowka D, Craighead HG, Baird B. Visualization of plasma membrane compartmentalization with patterned lipid bilayers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 13798-13803. PMID: 15356342, PMCID: PMC518836, DOI: 10.1073/pnas.0403835101.Peer-Reviewed Original ResearchConceptsLipid raftsLeaflet componentsPlasma membrane compartmentalizationReceptor clustersMembrane structural organizationLipid bilayersFcepsilon receptor ITyrosine phosphorylation activityMembrane compartmentalizationLyn kinaseInner leafletPhosphorylation activityActin polymerizationCellular componentsStructural organizationCell receptorRaftsCell activationReceptor IMast cell receptorsStructural reorganizationKinaseUnique insightsBilayersProtein