2019
Greater parental comfort with lower glucose targets in young children with Type 1 diabetes using continuous glucose monitoring
Van Name MA, Miller KM, Commissariat PV, Whitehouse AL, Harrington KR, Anderson BJ, Mantravadi MG, Levy W, DeSalvo DJ, Tamborlane WV, Hilliard ME, Laffel LM, DiMeglio LA. Greater parental comfort with lower glucose targets in young children with Type 1 diabetes using continuous glucose monitoring. Diabetic Medicine 2019, 36: 1508-1510. PMID: 31295359, PMCID: PMC7027357, DOI: 10.1111/dme.14074.Peer-Reviewed Original ResearchBenefits and Barriers of Continuous Glucose Monitoring in Young Children with Type 1 Diabetes
Hilliard ME, Levy W, Anderson BJ, Whitehouse AL, Commissariat PV, Harrington KR, Laffel LM, Miller KM, Van Name M, Tamborlane WV, DeSalvo DJ, DiMeglio LA. Benefits and Barriers of Continuous Glucose Monitoring in Young Children with Type 1 Diabetes. Diabetes Technology & Therapeutics 2019, 21: 493-498. PMID: 31287721, PMCID: PMC6708264, DOI: 10.1089/dia.2019.0142.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringCGM useDiabetes managementDiabetes careBenefits of CGMYoung childrenGlucose monitoringMean child ageChildren's diabetes careType 1 diabetes managementPainful insertionT1D durationParents of childrenGlucose excursionsImproved sleepClinical strategiesSemistructured qualitative interviewsType 1Parental comfortChild's ageChildrenBehavioural supportMultiple barriersParents' experiencesCaregivers
2017
Postprandial Dosing of Bolus Insulin in Patients with type 1 Diabetes: a Cross-sectional Study Using Data From the T1d Exchange Registry
Peters A, Van Name MA, Thorsted B, Piltoft JS, Tamborlane WV. Postprandial Dosing of Bolus Insulin in Patients with type 1 Diabetes: a Cross-sectional Study Using Data From the T1d Exchange Registry. Endocrine Practice 2017, 23: 1201-1209. PMID: 28704103, DOI: 10.4158/ep171813.or.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood GlucoseBlood Glucose Self-MonitoringChildChild, PreschoolCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetic KetoacidosisDrug Dosage CalculationsFemaleHumansHypoglycemiaInfantInsulinInsulin Infusion SystemsMaleMiddle AgedPostprandial PeriodRegistriesYoung AdultConceptsRapid-acting insulin analoguesLarger insulin doseT1D Exchange RegistryType 1 diabetesCross-sectional studyDiabetic ketoacidosisInsulin doseGreater prevalenceCurrent rapid-acting insulin analoguesInsulin analoguesSelf-monitoring blood glucosePercent of patientsCharacteristics of patientsPoor glycemic controlExclusion of patientsBody mass indexContinuous glucose monitoringPostprandial dosingGlycemic controlSevere hypoglycemiaBolus insulinMass indexEnrollment questionnaireBlood glucoseGlucose levels
2015
Prevalence of cardiovascular risk factors in youth with type 1 diabetes and elevated body mass index
Redondo MJ, Foster NC, Libman IM, Mehta SN, Hathway JM, Bethin KE, Nathan BM, Ecker MA, Shah AC, DuBose SN, Tamborlane WV, Hoffman RP, Wong JC, Maahs DM, Beck RW, DiMeglio LA. Prevalence of cardiovascular risk factors in youth with type 1 diabetes and elevated body mass index. Acta Diabetologica 2015, 53: 271-277. PMID: 26077171, DOI: 10.1007/s00592-015-0785-1.Peer-Reviewed Original ResearchConceptsType 1 diabetesCardiovascular risk factorsHealthy weight participantsWeight participantsRisk factorsElevated body mass indexHealthy weight peersFrequency of hypertensionDiagnosis of hypertensionHealthy weight childrenBody mass indexYears of ageWarrants further investigationConclusionsObese childrenMass indexObese participantsT1D ExchangeWeight childrenMedical recordsPrevention criteriaWeight statusAimThe prevalenceHigh prevalenceChildren 2Dyslipidemia
2014
Persistently high glucose levels in young children with type 1 diabetes
Tansey M, Beck R, Ruedy K, Tamborlane W, Cheng P, Kollman C, Fox L, Weinzimer S, Mauras N, White N, Tsalikian E, Network F. Persistently high glucose levels in young children with type 1 diabetes. Pediatric Diabetes 2014, 17: 93-100. PMID: 25496062, PMCID: PMC4465416, DOI: 10.1111/pedi.12248.Peer-Reviewed Original ResearchConceptsType 1 diabetesGlucose levelsMin/dContinuous glucose monitorGlycemic excursionsYoung childrenPostprandial glycemic excursionsSuboptimal glycemic controlPercent of participantsHigh glucose levelsOverall mean glucoseMean hemoglobinGlycemic targetsGlycemic controlMedian timeMean glucoseCGM metricsNormal rangeAge groupsT1DHyperglycemic rangeValue 71Age rangeCGM dataAge 8Contrasting the clinical care and outcomes of 2,622 children with type 1 diabetes less than 6 years of age in the United States T1D Exchange and German/Austrian DPV registries
Maahs DM, Hermann JM, DuBose SN, Miller KM, Heidtmann B, DiMeglio LA, Rami-Merhar B, Beck RW, Schober E, Tamborlane WV, Kapellen TM, Holl RW, for the DPV Initiative and the T1D Exchange Clinic Network. Contrasting the clinical care and outcomes of 2,622 children with type 1 diabetes less than 6 years of age in the United States T1D Exchange and German/Austrian DPV registries. Diabetologia 2014, 57: 1578-1585. PMID: 24893863, DOI: 10.1007/s00125-014-3272-2.Peer-Reviewed Original ResearchConceptsType 1 diabetesYounger patientsClinical outcomesT1D ExchangeTreatment modalitiesGerman/Austrian DPV registryAims/hypothesisThe studyFrequency of DKAProspective Diabetes FollowImproved metabolic controlRisk of DKAYears of ageDPV registryRegistry participantsAdolescent DiabetesHypothesisThe studyInjection usersClinical careMetabolic controlFrequency of SHT1DXAge groupsInsulin pumpParticipant characteristicsType 1Insulin pump use in young children in the T1D Exchange clinic registry is associated with lower hemoglobin A1c levels than injection therapy
Blackman SM, Raghinaru D, Adi S, Simmons JH, Ebner‐Lyon L, Chase HP, Tamborlane WV, Schatz DA, Block JM, Litton JC, Raman V, Foster NC, Kollman CR, DuBose SN, Miller KM, Beck RW, DiMeglio LA. Insulin pump use in young children in the T1D Exchange clinic registry is associated with lower hemoglobin A1c levels than injection therapy. Pediatric Diabetes 2014, 15: 564-572. PMID: 24494980, DOI: 10.1111/pedi.12121.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionT1D Exchange Clinic RegistryCross-sectional studyInjection usersClinic registryInitiation of CSIIUse of CSIIInsulin pumpLower hemoglobin A1c levelsDiabetic ketoacidosis eventsHemoglobin A1c levelsSevere hypoglycemia eventsSubcutaneous insulin infusionRetrospective longitudinal studyType 1 diabetesRisk of DKALongitudinal studyYounger age groupsYoung childrenRace/ethnicityKetoacidosis eventsAnnual household incomeT1D durationA1c levelsHemoglobin A1c
2013
Pediatric diabetes consortium T1D New Onset (NeOn) study: clinical outcomes during the first year following diagnosis
Cengiz E, Connor CG, Ruedy KJ, Beck RW, Kollman C, Klingensmith GJ, Tamborlane WV, Lee JM, Haller MJ, Consortium F. Pediatric diabetes consortium T1D New Onset (NeOn) study: clinical outcomes during the first year following diagnosis. Pediatric Diabetes 2013, 15: 287-293. PMID: 23944865, PMCID: PMC3844085, DOI: 10.1111/pedi.12068.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolCohort StudiesDiabetes Mellitus, Type 1Diabetic KetoacidosisDrug MonitoringFemaleFollow-Up StudiesGlycated HemoglobinHumansHyperglycemiaHypoglycemiaHypoglycemic AgentsIncidenceInfantInsulinKaplan-Meier EstimateMaleProportional Hazards ModelsProspective StudiesUnited StatesConceptsPediatric Diabetes ConsortiumDiabetic ketoacidosisClinical outcomesNatural historyFirst yearCourse of T1DDiagnosis of T1D.Onset of T1DTime of diagnosisSevere hypoglycemic eventsType 1 diabetesMean HbA1cMulticenter studyHypoglycemic eventsClinical measuresLarge cohortIntervention studiesDiagnosisFuture interventionsMonthsOnset StudyHbA1cT1D.T1DOutcomesPediatric Diabetes Consortium Type 1 Diabetes New Onset (NeOn) Study: factors associated with HbA1c levels one year after diagnosis
Redondo MJ, Connor CG, Ruedy KJ, Beck RW, Kollman C, Wood JR, Buckingham B, Klingensmith GJ, Silverstein J, Tamborlane WV, Consortium F. Pediatric Diabetes Consortium Type 1 Diabetes New Onset (NeOn) Study: factors associated with HbA1c levels one year after diagnosis. Pediatric Diabetes 2013, 15: 294-302. PMID: 23889707, PMCID: PMC3858510, DOI: 10.1111/pedi.12061.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood Glucose Self-MonitoringChildChild, PreschoolCohort StudiesDiabetes Mellitus, Type 1Diabetic KetoacidosisFemaleFollow-Up StudiesGlycated HemoglobinHumansHyperglycemiaHypoglycemiaHypoglycemic AgentsInfantInsulinMaleNuclear FamilyProspective StudiesSocioeconomic FactorsUnited StatesConceptsPediatric Diabetes ConsortiumLower insulin requirementsBody mass indexDiabetic ketoacidosisInsulin requirementsWhite raceNon-Hispanic white raceDeterminants of hemoglobinOnset of T1DType 1 diabetesLevels one yearHigher socioeconomic statusFirst yearPositive autoantibodiesSD HbA1cNew onsetMass indexBlood glucoseClinical centersDiabetes physiciansPrivate health insuranceTanner stageNumber of visitsFrequent SMBGIntervention studiesRace, Socioeconomic Status, and Treatment Center Are Associated with Insulin Pump Therapy in Youth in the First Year Following Diagnosis of Type 1 Diabetes
Lin MH, Connor CG, Ruedy KJ, Beck RW, Kollman C, Buckingham B, Redondo MJ, Schatz D, Haro H, Lee JM, Tamborlane WV, Wood F. Race, Socioeconomic Status, and Treatment Center Are Associated with Insulin Pump Therapy in Youth in the First Year Following Diagnosis of Type 1 Diabetes. Diabetes Technology & Therapeutics 2013, 15: 929-934. PMID: 23869706, PMCID: PMC3817890, DOI: 10.1089/dia.2013.0132.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBlood GlucoseBlood Glucose Self-MonitoringChildChild, PreschoolDiabetes Mellitus, Type 1Diabetic KetoacidosisFemaleHealth Services AccessibilityHealthcare DisparitiesHumansHypoglycemic AgentsInfantInfusion Pumps, ImplantableInsulinInsulin Infusion SystemsMaleMedically UninsuredSocioeconomic FactorsUnited StatesConceptsNon-Hispanic white raceInsulin pump therapyPump therapyPump useWhite raceFirst yearSocioeconomic statusPediatric diabetes centersTime of diagnosisType 1 diabetesPercent of participantsHigher socioeconomic statusAnnual household incomeNew onsetDiabetes CenterCox regressionT1D diagnosisPrivate health insuranceFollowing DiagnosisNumber of childrenTreatment centersMultivariate analysisTherapyType 1Early useChallenges and Future Directions of the T1D Exchange Clinic Network and Registry
Miller KM, Xing D, Tamborlane WV, Bergenstal RM, Beck RW. Challenges and Future Directions of the T1D Exchange Clinic Network and Registry. Journal Of Diabetes Science And Technology 2013, 7: 963-969. PMID: 23911177, PMCID: PMC3879760, DOI: 10.1177/193229681300700418.Peer-Reviewed Original ResearchConceptsT1D Exchange Clinic NetworkClinic registryClinic networkT1D Exchange Clinic RegistryType 1 diabetes mellitusPublic health issueElectronic health recordsDiabetes historyDiabetes mellitusDiabetes CenterMedical recordsInsulin administrationMedical conditionsWide age rangeWeb-based questionnaireRegistryAutoimmune T1DMHealth issuesHealth recordsAge rangeData extractionParticipant completionT1DMClinicLaboratory resultsMost Youth With Type 1 Diabetes in the T1D Exchange Clinic Registry Do Not Meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes Clinical Guidelines
Wood JR, Miller KM, Maahs DM, Beck RW, DiMeglio LA, Libman IM, Quinn M, Tamborlane WV, Woerner SE, . Most Youth With Type 1 Diabetes in the T1D Exchange Clinic Registry Do Not Meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes Clinical Guidelines. Diabetes Care 2013, 36: 2035-2037. PMID: 23340893, PMCID: PMC3687259, DOI: 10.2337/dc12-1959.Peer-Reviewed Original ResearchConceptsType 1 diabetesT1D Exchange Clinic RegistryBlood pressureClinic registryAmerican Diabetes Association goalsAmerican Diabetes AssociationT1D Exchange RegistryHbA1c targetDiabetes AssociationClinical guidelinesBMI goalPediatric endocrinologistsDiabetesProportion of youthMost childrenRegistryMajority of youthAssociation goalsTwo-thirdsInternational SocietyMost youthTarget levelYearsParticipantsBMI
2012
The T1D Exchange Clinic Registry
Beck RW, Tamborlane WV, Bergenstal RM, Miller KM, DuBose SN, Hall CA, Network F. The T1D Exchange Clinic Registry. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 4383-4389. PMID: 22996145, DOI: 10.1210/jc.2012-1561.Peer-Reviewed Original ResearchConceptsT1D Exchange Clinic RegistryClinic registryAutoimmune type 1 diabetesFirst-degree family membersClinic-based registrySevere hypoglycemic eventsChronic diabetic complicationsType 1 diabetesContinuous glucose monitoringAssessment of associationsDiabetes historyDiabetic ketoacidosisEndocrinology centersPatient characteristicsRenal diseaseChart extractionT1D ExchangeGlycosylated hemoglobinHypoglycemic eventsDiabetic complicationsRetinopathy treatmentGeneral healthFamily historyMedical conditionsRegistry
2005
Contrasting Challenges of Insulin Pump Therapy in a Toddler and Adolescent With Type 1 Diabetes
Doyle Boland EA, Steffen AT, Tamborlane WV. Contrasting Challenges of Insulin Pump Therapy in a Toddler and Adolescent With Type 1 Diabetes. The Science Of Diabetes Self-Management And Care 2005, 31: 584-590. PMID: 16100334, DOI: 10.1177/0145721705278888.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionType 1 diabetesGlycemic controlCSII therapyHypoglycemic episodesInsulin bolus dosesHemoglobin A1c levelsPediatric diabetes clinicSevere hypoglycemic episodesInsulin pump therapySubcutaneous insulin infusionYears of ageAge 13 yearsA1c levelsCatheter siteDiabetes clinicBolus dosesPump therapyDaily injectionsIdeal therapyInsulin infusionInsulin injectionsPostprandial hyperglycemiaFood intakePump use
2004
Persistence of Benefits of Continuous Subcutaneous Insulin Infusion in Very Young Children With Type 1 Diabetes: A Follow-up Report
Weinzimer SA, Ahern JH, Doyle EA, Vincent MR, Dziura J, Steffen AT, Tamborlane WV. Persistence of Benefits of Continuous Subcutaneous Insulin Infusion in Very Young Children With Type 1 Diabetes: A Follow-up Report. Pediatrics 2004, 114: 1601-1605. PMID: 15574621, DOI: 10.1542/peds.2004-0092.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionType 1 diabetesMultiple daily injectionsSubcutaneous insulin infusionSevere hypoglycemiaDaily injectionsInsulin infusionRate of SHMonths of CSIIYoung childrenEpisodes of DKAOlder pediatric patientsVery Young ChildrenPersistence of benefitHypoglycemia frequencyYounger patientsGlycemic controlPediatric patientsPump treatmentClinic databaseSafety dataEmergency treatmentAge groupsType 1Diabetes
2002
Mothers'Experiences Raising Young Children With Type 1 Diabetes
Sullivan‐Bolyai S, Deatrick J, Gruppuso P, Tamborlane W, Grey M. Mothers'Experiences Raising Young Children With Type 1 Diabetes. Journal For Specialists In Pediatric Nursing 2002, 7: 93-103. PMID: 12236249, DOI: 10.1111/j.1744-6155.2002.tb00158.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdaptation, PsychologicalAdultCaregiversCase-Control StudiesChild DevelopmentChild RearingChild, PreschoolDiabetes Mellitus, Type 1FemaleHumansInfantMaleMother-Child RelationsMothersNurse's RolePediatric NursingSeverity of Illness IndexSurveys and QuestionnairesUnited StatesConceptsMothers of childrenType 1 diabetesBurden of careChildren 4 yearsControl group mothersFear of hypoglycemiaSeizure activityPostdiagnosis periodGroup mothersMother-child observationsDiabetesMothers' concernsType 1Child's conditionDescriptive designMothersYoung childrenChildrenDaycare centersCommunity resourcesHypoglycemiaNursesCare