2006
The Effects of Aerobic Exercise on Glucose and Counterregulatory Hormone Concentrations in Children With Type 1 Diabetes
Tansey MJ, Tsalikian E, Beck RW, Mauras N, Buckingham BA, Weinzimer SA, Janz KF, Kollman C, Xing D, Ruedy KJ, Steffes MW, Borland TM, Singh RJ, Tamborlane WV. The Effects of Aerobic Exercise on Glucose and Counterregulatory Hormone Concentrations in Children With Type 1 Diabetes. Diabetes Care 2006, 29: 20-25. PMID: 16373890, PMCID: PMC2396943, DOI: 10.2337/diacare.29.01.06.dc05-1192.Peer-Reviewed Original ResearchConceptsType 1 diabetesOral glucoseNorepinephrine concentrationsAerobic exerciseExercise sessionsGrowth hormoneAcute glucose-lowering effectGlucose concentrationAerobic exercise resultsLow glucoseIncidence of hypoglycemiaExercise-induced increaseGlucose-lowering effectCounterregulatory hormone concentrationsTarget heart rateTreatment of hypoglycemiaPlasma glucose concentrationDl risePlasma glucagonPlasma glucoseBlood glucoseVs. 6Baseline glucoseBaseline valuesHeart rate
2003
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
Weiss R, Dufour S, Taksali SE, Tamborlane WV, Petersen KF, Bonadonna RC, Boselli L, Barbetta G, Allen K, Rife F, Savoye M, Dziura J, Sherwin R, Shulman GI, Caprio S. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. The Lancet 2003, 362: 951-957. PMID: 14511928, PMCID: PMC2995523, DOI: 10.1016/s0140-6736(03)14364-4.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceGlucose toleranceObese childrenInsulin resistanceObese adolescentsGlucose disposalInsulin sensitivitySevere peripheral insulin resistanceNon-oxidative glucose metabolismSubcutaneous fatH plasma glucose concentrationsAbdominal fat partitioningVisceral lipid contentsPeripheral glucose disposalHigher intramyocellular lipid contentAbdominal fat distributionDegree of obesityIntramyocellular lipid contentPeripheral insulin resistanceHigh visceral fatAbdominal subcutaneous fatEuglycaemic hyperinsulinaemic clampSevere insulin resistancePlasma glucose concentration
1995
Enhanced adrenomedullary response and increased susceptibility to neuroglycopenia: Mechanisms underlying the adverse effects of sugar ingestion in healthy children
Jones TW, Borg WP, Boulware SD, McCarthy G, Sherwin RS, Tamborlane WV. Enhanced adrenomedullary response and increased susceptibility to neuroglycopenia: Mechanisms underlying the adverse effects of sugar ingestion in healthy children. The Journal Of Pediatrics 1995, 126: 171-177. PMID: 7844661, DOI: 10.1016/s0022-3476(95)70541-4.Peer-Reviewed Original ResearchConceptsClinical Research CenterHealthy childrenPlasma glucose concentrationAdrenomedullary responseHypoglycemic clampSymptom scoresSugar ingestionStandard oral glucose loadOral glucose loadPlasma epinephrine levelsPlasma glucose levelsGlucose concentrationCognitive effectsSugar-free drinksP300 potentialEpinephrine levelsP300 auditoryGlucose loadInsulin levelsSymptomatic responsePlasma glucoseOral administrationGlucose levelsHormone concentrationsPhysiologic mechanisms