1994
Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults.
Boulware SD, Tamborlane WV, Rennert NJ, Gesundheit N, Sherwin RS. Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults. Journal Of Clinical Investigation 1994, 93: 1131-1139. PMID: 8132753, PMCID: PMC294058, DOI: 10.1172/jci117065.Peer-Reviewed Original ResearchConceptsRecombinant human insulin-like growth factorInsulin-like growth factorHuman insulin-like growth factorMiddle-aged subjectsC-peptideYoung subjectsBasal IGF-I levelsHealthy middle-aged subjectsGlucose uptakeGrowth factorAdverse metabolic changesFree fatty acid levelsIGF-I levelsRelative insulin deficiencyEuglycemic clamp studiesFat oxidation rateDose-response relationshipFatty acid levelsInsulin-induced stimulationMiddle-aged adultsBasal insulinInsulin deficiencyMetabolic effectsClamp studiesRhIGFMetabolic Effects of rhIGF-1 in Normal Human Subjects
Rennert NJ, Boulware SD, Kerr D, Caprio S, Tamborlane WV, Sherwin RS. Metabolic Effects of rhIGF-1 in Normal Human Subjects. Advances In Experimental Medicine And Biology 1994, 343: 311-318. PMID: 8184741, DOI: 10.1007/978-1-4615-2988-0_30.Peer-Reviewed Original ResearchConceptsRhIGF-1Hepatic glucose productionIGF-1Free fatty acidsGlucose productionGlucose uptakeEuglycemic clamp techniqueHuman IGF-1Normal human subjectsSpite of maintenanceSustained euglycemiaMetabolic effectsFFA levelsHypoglycemic effectClamp techniqueMetabolic actionsProfound reductionInsulinHypoglycemic hormoneFat cellsRatsComparable stimulationProtein breakdownSimilar extentEuglycemia
1991
Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats
Jacob RJ, Sherwin RS, Bowen L, Fryburg D, Fagin KD, Tamborlane WV, Shulman GI. Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats. American Journal Of Physiology 1991, 260: e262-e268. PMID: 1996629, DOI: 10.1152/ajpendo.1991.260.2.e262.Peer-Reviewed Original ResearchConceptsBB/W ratsBeta-hydroxybutyrate levelsDiabetic ratsNondiabetic ratsGlucose uptakeW ratsDiabetic BB/W ratsGlucose productionInsulin-like growth factor IIGF-I infusionDiabetic BB ratsInsulin-dependent diabetesMetabolic responseGrowth factor IHepatic glucose productionInsulin-stimulated glucose uptakeGlucose production rateBB ratsMetabolic effectsSimilar twofold increaseIGFRatsFactor IInsulinKetone concentrations