2017
Initial Presentation of Type 2 Diabetes in Adolescents Predicts Durability of Successful Treatment with Metformin Monotherapy: Insights from the Pediatric Diabetes Consortium T2D Registry
Bacha F, Cheng P, Gal RL, Kollman C, Tamborlane WV, Klingensmith GJ, Manseau K, Wood J, Beck RW. Initial Presentation of Type 2 Diabetes in Adolescents Predicts Durability of Successful Treatment with Metformin Monotherapy: Insights from the Pediatric Diabetes Consortium T2D Registry. Hormone Research In Paediatrics 2017, 89: 47-55. PMID: 29131017, DOI: 10.1159/000481687.Peer-Reviewed Original ResearchConceptsMetformin monotherapyType 2 diabetesLower HbA1cGroup 2Shorter diabetes durationYear of diagnosisAdequate controlDiabetes durationT2D durationGlycemic controlInitial presentationMultivariable analysisBMI percentileSuccessful treatmentBACKGROUND/Early diagnosisMonotherapyTherapy highlightGroup 1HbA1cMetabolic controlMetforminDiagnosisGreater likelihoodRapid deterioration
1991
Insulin Resistance: An Early Metabolic Defect of Turner's Syndrome*
CAPRIO S, BOULWARE S, DIAMOND M, SHERWIN R, CARPENTER TO, RUBIN K, AMIEL S, PRESS M, TAMBORLANE W. Insulin Resistance: An Early Metabolic Defect of Turner's Syndrome*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 832-836. PMID: 2005209, DOI: 10.1210/jcem-72-4-832.Peer-Reviewed Original ResearchConceptsInsulin-stimulated glucose metabolismEarly metabolic defectsNormal controlsGlucose metabolismTurner syndromeEuglycemic clampInsulin resistanceGroup 2Metabolic defectsTurner patientsAge-matched normal controlsChain amino acid levelsGroup of patientsRisk of diabetesNonoxidative glucose disposalIntracellular glucose metabolismWhole-body glucoseHepatic glucose productionNondiabetic patientsEstrogen therapyHormone therapyYounger patientsGlucose disposalHepatic sensitivityInsulin sensitivity