2008
Effect of a Successful Intensive Lifestyle Program on Insulin Sensitivity and Glucose Tolerance in Obese Youth
Shaw M, Savoye M, Cali A, Dziura J, Tamborlane WV, Caprio S. Effect of a Successful Intensive Lifestyle Program on Insulin Sensitivity and Glucose Tolerance in Obese Youth. Diabetes Care 2008, 32: 45-47. PMID: 18840769, PMCID: PMC2606827, DOI: 10.2337/dc08-0808.Peer-Reviewed Original ResearchConceptsIntensive lifestyle programLifestyle programInsulin sensitivityObese youthBody fatGlucose metabolismLarge randomized clinical trialsOral glucose tolerance testGlucose tolerance testRandomized clinical trialsGlucose toleranceObese childrenControl subjectsTolerance testClinical trialsBody compositionBody weightSubject changesGreater decreaseSubjectsFatMetabolismBMIResearch designBright bodies
2007
Degree of Obesity and Glucose Allostasis Are Major Effectors of Glucose Tolerance Dynamics in Obese Youth
Weiss R, Cali AM, Dziura J, Burgert TS, Tamborlane WV, Caprio S. Degree of Obesity and Glucose Allostasis Are Major Effectors of Glucose Tolerance Dynamics in Obese Youth. Diabetes Care 2007, 30: 1845-1850. PMID: 17475938, DOI: 10.2337/dc07-0325.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testDegree of obesityElevated glucose levelsObese youthGlucose toleranceAmbient glycemiaInsulin sensitivityGlucose levelsSecond oral glucose tolerance testBaseline BMI z-scoreGlucose tolerance testBMI z-scoreAltered glucose metabolismCross-sectional analysisTolerance testInsulin sensitizationGlucose metabolismObesityZ-scoreLongitudinal assessmentLongitudinal changesMajor effectorGlycemiaSignificant reduction
2006
Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents
Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S. Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents. Diabetologia 2006, 49: 571-579. PMID: 16456682, DOI: 10.1007/s00125-005-0109-z.Peer-Reviewed Original ResearchConceptsEarly insulin responseObese childrenInsulin resistanceInsulin clearanceInsulin responseAims/hypothesisThe prevalenceObesity-related insulin resistanceOral glucose loadLower insulin clearanceType 2 diabetesAcute insulin responseGlucose tolerance levelsAltered glucose metabolismSevere insulin resistanceBeta-cell adaptationAfrican American subjectsEthnic groupsHypothesisThe prevalenceGlucose toleranceGlucose loadInsulin sensitivityGlucose metabolismMethodsSeven hundredClearanceHispanic origin
2003
Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation
Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation. Diabetes 2003, 52: 663-666. PMID: 12606506, DOI: 10.2337/diabetes.52.3.663.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesVentromedial hypothalamusHormone responseSprague-Dawley ratsGlucose-sensing mechanismHypoglycemic counterregulationSystemic hypoglycemiaHormonal suppressionLactate perfusionApproximate fourfold increaseGlucose metabolismMicrodialysis perfusionGlucose perfusionHormonal responsesHypoglycemic plateauHypoglycemiaPerfusionL-lactateExogenous glucoseFourfold increaseGlucoseLactate
1994
Effects of puberty and diabetes on metabolism of insulin-sensitive fuels
Caprio S, Cline G, Boulware S, Permanente C, Shulman GI, Sherwin RS, Tamborlane WV. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. American Journal Of Physiology 1994, 266: e885-e891. PMID: 8023918, DOI: 10.1152/ajpendo.1994.266.6.e885.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusIDDM adolescentsEffect of pubertyGlucose metabolismNondiabetic groupIDDM subjectsInsulin infusionHealthy controlsLeucine fluxHealthy young adult controlsLow-dose insulin infusionPlasma free fatty acid levelsFree fatty acid levelsYoung adult controlsFatty acid levelsAction of insulinLeucine oxidation rateAmino acid/protein metabolismEuglycemic hyperinsulinemiaDiabetes mellitusInsulin resistanceInsulin valuesBasal glucosePlasma insulinNormal puberty
1991
Insulin Resistance: An Early Metabolic Defect of Turner's Syndrome*
CAPRIO S, BOULWARE S, DIAMOND M, SHERWIN R, CARPENTER TO, RUBIN K, AMIEL S, PRESS M, TAMBORLANE W. Insulin Resistance: An Early Metabolic Defect of Turner's Syndrome*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 832-836. PMID: 2005209, DOI: 10.1210/jcem-72-4-832.Peer-Reviewed Original ResearchConceptsInsulin-stimulated glucose metabolismEarly metabolic defectsNormal controlsGlucose metabolismTurner syndromeEuglycemic clampInsulin resistanceGroup 2Metabolic defectsTurner patientsAge-matched normal controlsChain amino acid levelsGroup of patientsRisk of diabetesNonoxidative glucose disposalIntracellular glucose metabolismWhole-body glucoseHepatic glucose productionNondiabetic patientsEstrogen therapyHormone therapyYounger patientsGlucose disposalHepatic sensitivityInsulin sensitivityInsulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*
AMIEL S, CAPRIO S, SHERWIN R, PLEWE G, HAYMOND M, TAMBORLANE W. Insulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 277-282. PMID: 1991798, DOI: 10.1210/jcem-72-2-277.Peer-Reviewed Original ResearchConceptsPeripheral glucose metabolismInsulin resistancePubertal childrenGlucose metabolismHigher insulin doseMU/m2Hyperglycemic clamp studiesEuglycemic insulin clampEnhanced insulin responseHepatic glucose productionSelective insulin resistanceChain amino acidsHealthy prepubertalCompensatory hyperinsulinemiaInsulin doseInsulin clampPeripheral glucoseInsulin responsePlasma levelsPrepubertal childrenClamp studiesProtein anabolismNormal pubertyGlucose productionAmino acid metabolism
1988
Insulin Resistance and Hyperinsulinemia in Patients with Thalassemia Major Treated by Hypertransfusion
Merkel PA, Simonson DC, Amiel SA, Plewe G, Sherwin RS, Pearson HA, Tamborlane WV. Insulin Resistance and Hyperinsulinemia in Patients with Thalassemia Major Treated by Hypertransfusion. New England Journal Of Medicine 1988, 318: 809-814. PMID: 3281000, DOI: 10.1056/nejm198803313181303.Peer-Reviewed Original ResearchConceptsInsulin resistanceInsulin levelsThalassemia majorInsulin-stimulated glucose metabolismC-peptide levelsDevelopment of diabetesOral glucose administrationPlasma insulin levelsHypertransfusion therapyPubertal patientsPrepubertal patientsDiabetes mellitusGlucose toleranceInsulin deficiencyPubertal childrenGlucose administrationInsulin secretionIron overloadPrepubertal childrenChelation therapyPubertal subjectsGlucose metabolismBeta cellsHyperglycemic stimulusPatients