2000
Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia*
Garcia-Ocaña A, Takane K, Syed M, Philbrick W, Vasavada R, Stewart A. Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia*. Journal Of Biological Chemistry 2000, 275: 1226-1232. PMID: 10625667, DOI: 10.1074/jbc.275.2.1226.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorRat insulin II promoterBeta-cell proliferationDiabetogenic effectMild hypoglycemiaIslet massInsulin contentOverexpression of HGFIslet numberInsulin productionBeta-cell replication rateRole of HGFHepatocyte growth factor overexpressionProliferation of isletsBeta-cell massCell proliferationGrowth factor overexpressionMesenchyme-derived cellsPancreatic areaCell replication ratesFasting statesNormal littermatesTransgenic miceHGF mRNAIslet cells
1996
Overexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia (∗)
Vasavada R, Cavaliere C, D'Ercole A, Dann P, Burtis W, Madlener A, Zawalich K, Zawalich W, Philbrick W, Stewart A. Overexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia (∗). Journal Of Biological Chemistry 1996, 271: 1200-1208. PMID: 8557651, DOI: 10.1074/jbc.271.2.1200.Peer-Reviewed Original ResearchConceptsRat insulin II promoterInsulin secretionIslet massPancreatic isletsNormal littermatesHormone-related proteinBlood glucose valuesTotal islet massIslet perifusion studiesNormal physiologic roleInappropriate hyperinsulinemiaParathyroid hormoneIslet hyperplasiaInsulin concentrationsTotal islet numberAutocrine roleGlucose homeostasisPerifusion studiesTransgenic miceGlucose valuesIslet numberIslet cellsPhysiologic rolePTHrPMice