Small‐Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α
Buckley DL, Gustafson JL, Van Molle I, Roth AG, Tae HS, Gareiss PC, Jorgensen WL, Ciulli A, Crews CM. Small‐Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α. Angewandte Chemie International Edition 2012, 51: 11463-11467. PMID: 23065727, PMCID: PMC3519281, DOI: 10.1002/anie.201206231.Peer-Reviewed Original ResearchConceptsNovel small molecule inhibitorSmall molecule inhibitorsTranscription factorsSub-micromolar inhibitorsInhibitor bindsMolecule inhibitorsOxygen sensingHIF1αInhibitorsLigase