2022
Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability
Lee KS, Hagan CN, Hughes M, Cotter G, Freud E, Kircanski K, Leibenluft E, Brotman MA, Tseng WL. Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 208-229. PMID: 35944754, PMCID: PMC9892288, DOI: 10.1016/j.jaac.2022.05.014.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFMRI studyNeurocognitive functionNeural convergenceActivation likelihood estimationLow frustration toleranceIrritability measuresFrequent temper tantrumsSample characteristicsCognitive controlFMRI taskEmotional reactivityStimulus typeFMRI resultsChildhood irritabilityFrustration toleranceNeural mechanismsFunctional neuroimagingTransdiagnostic symptomsTask domainTemper tantrumsFMRI methodsNeuroscience databasesNull findingsCoordinate-based dataCharacterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®
Lee KS, Xiao J, Luo J, Leibenluft E, Liew Z, Tseng WL. Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®. Frontiers In Psychiatry 2022, 13: 803891. PMID: 35308882, PMCID: PMC8931695, DOI: 10.3389/fpsyt.2022.803891.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderResponse inhibitionError processingNeural correlatesIrritability symptomsHyperactivity disorderHigher attention-deficit/hyperactivity disorderAdolescent Brain Cognitive Development (ABCD) studySymptoms of inattentionDifferential neural mechanismsCognitive Development StudyStop-signal taskLow frustration toleranceLatent class analysisFronto-parietal regionsLatent variable modelingPediatric irritabilityNeural differencesIndividual differencesSignal taskExecutive dysfunctionFrustration toleranceNeural mechanismsABCD studyHigh irritability
2021
Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability
Tseng WL, Abend R, Gold AL, Brotman MA. Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability. Journal Of Affective Disorders 2021, 295: 920-929. PMID: 34706463, PMCID: PMC8554134, DOI: 10.1016/j.jad.2021.08.117.Peer-Reviewed Original ResearchConceptsHigh negative affectivityNegative affectivityThreat appraisalPediatric anxietyAnxiety disordersThreat-safety discriminationWhole-brain activationLinear mixed effects analysisNegative affectivity factorExtinction recallThreat conditioningThreat contingenciesElevated irritabilityNeural correlatesTransdiagnostic sampleGreater prefrontalOccipital activationUnique varianceExplicit recallThreat responsesFMRI paradigmNeural mechanismsTask conditionsAmygdala connectivityMixed effects analysisFunctional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2020
Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability
Tseng WL. Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 1327-1329. PMID: 32966839, PMCID: PMC8143431, DOI: 10.1016/j.jaac.2020.09.008.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderAttention-deficit/hyperactivity disorderOppositional defiant disorderLong-term impairmentDSM-5 categoriesPediatric disordersHigh suicidalityAnxiety disordersHyperactivity disorderDisordersIrritabilityDefiant disorderHallmark featurePediatric irritabilityTransdiagnostic symptomsNeural mechanismsTransdiagnostic approachAutism spectrum disorderChild psychiatrySpectrum disorder
2018
A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces
2013
A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders
Tseng WL, Leibenluft E, Brotman MA. A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders. 2013, 16: 297-317. PMID: 24281907, PMCID: PMC4482127, DOI: 10.1007/7854_2013_252.Peer-Reviewed Original ResearchConceptsPediatric moodAnxiety disordersFunctional magnetic resonance imaging (fMRI) researchSystems neuroscience approachMagnetic resonance imaging researchNeuroscience approachEmotional dysregulationNeural mechanismsBehavioral findingsCore featuresImaging researchMoodFuture researchPotential novel treatmentDisordersNovel treatmentsResearchBrainFindingsChapterPathophysiologyRelationshipDysregulationAbnormalities