2009
Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs)
Kernan WN, Viscoli CM, DeMarco D, Mendes B, Shrauger K, Schindler JL, McVeety JC, Sicklick A, Moalli D, Greco P, Bravata DM, Eisen S, Resor L, Sena K, Story D, Brass LM, Furie KL, Gutmann L, Hinnau E, Gorman M, Lovejoy AM, Inzucchi SE, Young LH, Horwitz RI. Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs). Neurology 2009, 72: 1345-1351. PMID: 19365056, PMCID: PMC2677492, DOI: 10.1212/wnl.0b013e3181a0fda3.Peer-Reviewed Original ResearchConceptsOutreach NetworkCentral coordinating centerInsulin Resistance InterventionSecondary stroke preventionNames of patientsResults of surveillanceStroke preventionMore patientsStroke siteConnecticut hospitalsTrial participantsHome visitsPatientsResistance InterventionPersonal physicianElectronic admissionRandomization ratesCoordinating CenterMore rapid completionMonthsHigher enrollment ratesHospitalRecruitment strategiesTrialsParticipants
2005
Estrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST)
Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. Estrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST). American Journal Of Obstetrics And Gynecology 2005, 192: 387-393. PMID: 15695976, DOI: 10.1016/j.ajog.2004.08.017.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationEstrogen therapyCognitive declineNormal Mini-Mental State ExaminationDouble-blind trialSecondary stroke preventionTransient ischemic attackIschemic attackPostmenopausal womenStroke preventionRecent strokeStroke trialsCerebrovascular diseaseWomen's EstrogenEstradiol-17betaState ExaminationCognitive measuresEstrogenWomenNormal functionDomain measuresLess declineTherapyStrokeRisk
2000
Blood Pressure Exceeding National Guidelines Among Women After Stroke
Kernan W, Viscoli C, Brass L, Makuch R, Sarrel P, Horwitz R. Blood Pressure Exceeding National Guidelines Among Women After Stroke. Stroke 2000, 31: 415-419. PMID: 10657415, DOI: 10.1161/01.str.31.2.415.Peer-Reviewed Original ResearchConceptsHistory of hypertensionBlood pressure valuesNational guidelinesBlood pressureFirst examinationTrial of estrogenSecondary stroke preventionTransient ischemic attackBlood pressure controlTreatment of hypertensionProportion of womenIschemic attackSevere hypertensionStroke preventionSecondary preventionDiabetic patientsMean ageHypertensionPatientsPressure valuesPersonal physicianPressure controlSeparate guidelinesStrokeWomen
1998
Estrogen after ischemic stroke: Clinical basis and design of The Women's Estrogen for Stroke Trial
Kernan W, Brass L, Viscoli C, Sarrel P, Makuch R, Horwitz R. Estrogen after ischemic stroke: Clinical basis and design of The Women's Estrogen for Stroke Trial. Journal Of Stroke And Cerebrovascular Diseases 1998, 7: 85-95. PMID: 17895061, DOI: 10.1016/s1052-3057(98)80026-8.Peer-Reviewed Original ResearchIschemic strokeStroke trialsWomen's EstrogenSecondary stroke preventionStroke risk factorsTransient ischemic attackTime of strokeUse of estrogenEffectiveness of estrogenIschemic attackRecurrent strokeEstrogen usersPostmenopausal womenStroke preventionUterine bleedingEndometrial hyperplasiaAsymptomatic womenVaginal ultrasonographyUterine cancerRisk factorsImproved outcomesObservational studyTherapeutic effectClinical basisExclusion criteria