Clinical Evaluation of Ganaxolone in Pediatric and Adolescent Patients with Refractory Epilepsy
Pieribone VA, Tsai J, Soufflet C, Rey E, Shaw K, Giller E, Dulac O. Clinical Evaluation of Ganaxolone in Pediatric and Adolescent Patients with Refractory Epilepsy. Epilepsia 2007, 48: 1870-1874. PMID: 17634060, DOI: 10.1111/j.1528-1167.2007.01182.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnticonvulsantsChildChild, PreschoolDose-Response Relationship, DrugDrug Administration ScheduleEpilepsyFemaleHumansMalePilot ProjectsPregnanoloneTreatment OutcomeConceptsRefractory epilepsyAdverse eventsPilot studyDose escalation scheduleExtension periodDose-escalation trialEscalation scheduleSubstantial respondersAntiepileptic therapyTreat analysisGeneralized epilepsyModerate respondersAdolescent patientsClinical evaluationGanaxoloneClinical studiesPediatric subjectsPotential efficacyAnticonvulsant activityEpilepsyAdolescent subjectsOral suspensionExtension phaseDose rangeFurther studies