1974
Clinical antitumor activity and toxicity of streptozotocin (NSC‐85998)
Schein P, O'Connell M, Blom J, Hubbard S, Magrath I, Bergevin P, Wiernik P, Ziegler J, Devita V. Clinical antitumor activity and toxicity of streptozotocin (NSC‐85998). Cancer 1974, 34: 993-1000. PMID: 4371075, DOI: 10.1002/1097-0142(197410)34:4<993::aid-cncr2820340404>3.0.co;2-t.Peer-Reviewed Original ResearchConceptsMalignant carcinoid tumorsNormal renal functionIslet cell carcinomaClinical antitumor activityAcute lymphocytic leukemiaToxicity of streptozotocinHematologic toxicityAdvanced malignanciesRenal damageRenal functionCarcinoid tumorsHodgkin's diseaseCell carcinomaLymphocytic lymphomaTherapeutic responseLymphocytic leukemiaTumor massBurkitt's lymphomaDrug effectsMaximum dosesPatientsTotal doseStreptozotocinLymphomaAntitumor activityTreatment of malignant melanoma with methyl CCNU
Young R, Canellos G, Chabner B, Schein P, Brereton H, DeVita V. Treatment of malignant melanoma with methyl CCNU. Clinical Pharmacology & Therapeutics 1974, 15: 617-622. PMID: 4601745, DOI: 10.1002/cpt1974156617.Peer-Reviewed Original Research
1973
Streptozotocin for malignant insulinomas and carcinoid tumor. Report of eight cases and review of the literature.
Schein P, Kahn R, Gorden P, Wells S, Devita V. Streptozotocin for malignant insulinomas and carcinoid tumor. Report of eight cases and review of the literature. JAMA Internal Medicine 1973, 132: 555-61. PMID: 4355081, DOI: 10.1001/archinte.132.4.555.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Islet CellAdultBlood GlucoseCarcinoid TumorChemical and Drug Induced Liver InjuryCreatinineFemaleFollow-Up StudiesHumansInsulinKidneyKidney Function TestsLiverLiver NeoplasmsMaleMiddle AgedNeoplasm MetastasisPancreatic NeoplasmsProinsulinProteinuriaRadionuclide ImagingRemission, SpontaneousStreptozocinTime FactorsTolbutamide
1970
Pentamidine: Clinical pharmacologic correlations in man and mice
Waalkes T, Denham C, DeVita V. Pentamidine: Clinical pharmacologic correlations in man and mice. Clinical Pharmacology & Therapeutics 1970, 11: 505-512. PMID: 5310706, DOI: 10.1002/cpt1970114505.Peer-Reviewed Original ResearchConceptsDiffuse interstitial pneumoniaInterstitial pneumoniaUrinary excretionPlasma levelsPneumocystis cariniiSingle intraperitoneal injectionTypes of pneumoniaDosage scheduleCancer patientsMalignant diseaseRenal abnormalitiesConcomitant useIntraperitoneal injectionIntramuscular administrationOrgan transplantationExcretion patternsPatientsPneumoniaPentamidineExcretionDrugsMenDiseaseMiceCariniihe determination of pentamidine (4,4'-diamidinophenoxypentane) in plasma, urine, and tissues.
Waalkes T, DeVita V. he determination of pentamidine (4,4'-diamidinophenoxypentane) in plasma, urine, and tissues. Translational Research 1970, 75: 871-8. PMID: 5442852.Peer-Reviewed Original Research
1969
Pneumocystis carinii Pneumonia — Successful Diagnosis and Treatment of Two Patients with Associated Malignant Processes
DeVita V, Emmer M, Levine A, Jacobs B, Berard C. Pneumocystis carinii Pneumonia — Successful Diagnosis and Treatment of Two Patients with Associated Malignant Processes. New England Journal Of Medicine 1969, 280: 287-291. PMID: 5303991, DOI: 10.1056/nejm196902062800602.Peer-Reviewed Original ResearchConceptsNeedle biopsyMalignant processPentamidine isethionatePneumocystis carinii pneumoniaProper clinical settingPotential renal toxicityRenal functionAdequate therapyCarinii pneumoniaRenal toxicityPneumocystis infectionTubular disordersTherapeutic efficacyClinical settingFurther experiencePatientsBiopsyIsethionateTherapyInfectionDiagnosisValid assessmentPneumoniaPhysiciansDose