Whole body hyperthermia: a phase-I trial of a potential adjuvant to chemotherapy.
Bull J, Lees D, Schuette W, Whang-Peng J, Smith R, Bynum G, Atkinson E, Gottdiener J, Gralnick H, Shawker T, DeVita V. Whole body hyperthermia: a phase-I trial of a potential adjuvant to chemotherapy. Annals Of Internal Medicine 1979, 90: 317-23. PMID: 426399, DOI: 10.7326/0003-4819-90-3-317.Peer-Reviewed Original ResearchConceptsWhole-body hyperthermiaBody hyperthermiaFlow-directed pulmonary artery catheterEvidence of cardiac damageCreatine phosphokinasePhase I trialPulmonary artery catheterAdjuvant to chemotherapySerum CPK valuesPhase I cancer trialsSystemic chemotherapyClotting abnormalitiesIntravenous analgesiaCardiac indexSerum magnesiumGranulocyte countAcute fallArtery catheterCardiac damageTransient elevationPeripheral neuropathyAcute riseArterial pHLiver enzymesWater-perfused suit