Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration
Fang Y, Gupta V, Karra R, Holdway JE, Kikuchi K, Poss KD. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 13416-13421. PMID: 23901114, PMCID: PMC3746860, DOI: 10.1073/pnas.1309810110.Peer-Reviewed Original ResearchConceptsHeart regenerationSTAT3 inhibitionCertain lower vertebratesZebrafish heart regenerationRibosome affinity purificationTranslational profilingProgram essentialLower vertebratesAffinity purificationPathway membersSTAT3-dependent mannerZebrafish cardiomyocytesCardiomyocyte proliferationAnimal growthInjury-induced proliferationDynamic inductionProliferationCardiomyocytesInjury responseRegenerationRln3aVertebratesCardiogenesisRNAInhibitionAn Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle
Gupta V, Gemberling M, Karra R, Rosenfeld GE, Evans T, Poss KD. An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle. Current Biology 2013, 23: 1221-1227. PMID: 23791730, PMCID: PMC3759223, DOI: 10.1016/j.cub.2013.05.028.Peer-Reviewed Original ResearchConceptsVentricular wallCortical layersNormal cardiac functionHeart regenerationHeart failureCardiac damageCardiac functionCardiac ventriclesExpression of GATA4Cellular mechanismsBiomechanical stressCardiomyocytesTransgenic inhibitionGATA4 activityMuscleVentricleZebrafish heart regenerationAdultsDynamic cellular mechanismsClonal analysisOrganismal growthDevelopmental programClonal plasticityJuvenile zebrafishGATA4