Veer Sangha
Research
Publications
2024
Characterizing the progression of subclinical cardiac amyloidosis through artificial intelligence applied to electrocardiographic images and echocardiograms
Oikonomou E, Sangha V, Coppi A, Krumholz H, Miller E, Khera R. Characterizing the progression of subclinical cardiac amyloidosis through artificial intelligence applied to electrocardiographic images and echocardiograms. European Heart Journal 2024, 45: ehae666.2089. DOI: 10.1093/eurheartj/ehae666.2089.Peer-Reviewed Original ResearchDiagnosis of ATTR-CMATTR-CMBone scintigraphy scansClinical diagnosisTransthyretin amyloid cardiomyopathyMonths of diagnosisSex-matched controlsElectrocardiographic (ECGIndolent courseCardiac amyloidosisScintigraphy scanAmyloid cardiomyopathyEchocardiographic studiesAI-ECGEchocardiogramEventual diagnosisDetect longitudinal changesConfirmatory testDiagnosisClinical diseasePercentage of individualsLongitudinal changesECGMedianMonthsArtificial intelligence applied to electrocardiographic images for scalable screening of cardiac amyloidosis
Sangha V, Oikonomou E, Krumholz H, Miller E, Khera R. Artificial intelligence applied to electrocardiographic images for scalable screening of cardiac amyloidosis. European Heart Journal 2024, 45: ehae666.3436. DOI: 10.1093/eurheartj/ehae666.3436.Peer-Reviewed Original ResearchATTR-CMBone scintigraphy scansTransthyretin amyloid cardiomyopathyPositive predictive valueAI-ECG algorithmCardiac amyloidosisScintigraphy scanAmyloid cardiomyopathyAI-ECGSex-matchedDevelopment cohortMyocardial remodelingUnder-diagnosedUnder-treatedMatched controlsPredictive valueUnder-recognizedTransthyretin stabilizersConvolutional neural networkPatientsECGArtificial intelligenceHospitalPrevalenceTransthyretinArtificial intelligence applied to electrocardiographic images for the risk stratification of cancer therapeutics-related cardiac dysfunction
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial intelligence applied to electrocardiographic images for the risk stratification of cancer therapeutics-related cardiac dysfunction. European Heart Journal 2024, 45: ehae666.3190. DOI: 10.1093/eurheartj/ehae666.3190.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionImmune checkpoint inhibitorsGlobal longitudinal strainLeft ventricular systolic dysfunctionNon-Hodgkin's lymphomaCardiac dysfunctionAI-ECGNegative control analysesAssociated with higher incidenceVentricular systolic dysfunctionCohort of patientsRisk stratification strategiesCheckpoint inhibitorsTrastuzumab exposureSystolic dysfunctionRisk stratificationBreast cancerRisk biomarkersSecondary outcomesLongitudinal strainStratification strategiesTrastuzumabPatientsHigher incidenceAnthracyclinesDetection of ATTR cardiac amyloidosis using a novel artificial intelligence algorithm for wearable-adapted noisy single-lead electrocardiograms
Sangha V, Oikonomou E, Khunte A, Miller E, Khera R. Detection of ATTR cardiac amyloidosis using a novel artificial intelligence algorithm for wearable-adapted noisy single-lead electrocardiograms. European Heart Journal 2024, 45: ehae666.3438. DOI: 10.1093/eurheartj/ehae666.3438.Peer-Reviewed Original ResearchReal-world noiseSingle-lead ECGArtificial intelligence algorithmsMultiple signal-to-noise ratiosCommunity-dwelling adultsSignal-to-noise ratioIntelligence algorithmsATTR-CMMatched controlsECG signalsDevelopment cohortPreventive careHealthcare servicesBlack adultsHospital systemCommunity screeningAlgorithmBone scintigraphy scansATTR cardiac amyloidosisPrevalence levelsOnset of symptomsPositive predictive valuePrevalenceAI-ECG algorithmSex-matchedA multilabel deep learning model for the detection of conduction and rhythm disorders from PDF outputs of a widely available portable ECG Device
Sangha V, Dhingra L, Khera R. A multilabel deep learning model for the detection of conduction and rhythm disorders from PDF outputs of a widely available portable ECG Device. European Heart Journal 2024, 45: ehae666.3437. DOI: 10.1093/eurheartj/ehae666.3437.Peer-Reviewed Original ResearchDeep learning modelsPDF outputArtificial intelligenceLearning modelsConvolutional neural networkPortable devicesPortable ECG deviceMultilabel modelEfficientNet-B3Neural networkECG outputWearable ECGHeld-out subsetCurrent algorithmsSingle-lead ECGSynthetic ECGECG deviceWearableClinical ECGClinical labelsAlgorithmCommercial devicesDetection of conductivityNo current algorithmPDFArtificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images.
Oikonomou E, Sangha V, Dhingra L, Aminorroaya A, Coppi A, Krumholz H, Baldassarre L, Khera R. Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images. Circulation Cardiovascular Quality And Outcomes 2024 PMID: 39221857, DOI: 10.1161/circoutcomes.124.011504.Peer-Reviewed Original ResearchCancer therapeutics-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular systolic dysfunctionCardiac dysfunctionBreast cancerNon-Hodgkin lymphoma therapyNon-Hodgkin's lymphomaVentricular systolic dysfunctionAssociated with worse global longitudinal strainRisk stratification strategiesHigh-risk groupMonths post-treatmentPost hoc analysisElectrocardiographic (ECGTrastuzumab exposureLymphoma therapySystolic dysfunctionAI-ECGBefore treatmentRisk biomarkersLongitudinal strainLow riskStratification strategiesHigher incidencePositive screenA WEARABLE-ADAPTED ARTIFICIAL INTELLIGENCE ALGORITHM FOR HEART FAILURE PREDICTION FROM SINGLE-LEAD ELECTROCARDIOGRAMS IN A LARGE NATIONWIDE COHORT STUDY
Dhingra L, Aminorroaya A, Oikonomou E, Sangha V, Khunte A, Khera R. A WEARABLE-ADAPTED ARTIFICIAL INTELLIGENCE ALGORITHM FOR HEART FAILURE PREDICTION FROM SINGLE-LEAD ELECTROCARDIOGRAMS IN A LARGE NATIONWIDE COHORT STUDY. Journal Of The American College Of Cardiology 2024, 83: 2341. DOI: 10.1016/s0735-1097(24)04331-6.Peer-Reviewed Original ResearchHEART FAILURE RISK PREDICTION USING ARTIFICIAL INTELLIGENCE ON ECG PHOTOS IN LARGE CONTEMPORARY COHORT
Dhingra L, Sangha V, Aminorroaya A, Camargos A, Oikonomou E, Khera R. HEART FAILURE RISK PREDICTION USING ARTIFICIAL INTELLIGENCE ON ECG PHOTOS IN LARGE CONTEMPORARY COHORT. Journal Of The American College Of Cardiology 2024, 83: 277. DOI: 10.1016/s0735-1097(24)02267-8.Peer-Reviewed Original ResearchUSING PHOTOS OF ELECTROCARDIOGRAMS AS A BIOMARKER FOR CARDIOVASCULAR RISK - A MULTINATIONAL ASSESSMENT OF A NOVEL ARTIFICIAL INTELLIGENCE APPROACH
Sangha V, Dhingra L, Aminorroaya A, Khera R. USING PHOTOS OF ELECTROCARDIOGRAMS AS A BIOMARKER FOR CARDIOVASCULAR RISK - A MULTINATIONAL ASSESSMENT OF A NOVEL ARTIFICIAL INTELLIGENCE APPROACH. Journal Of The American College Of Cardiology 2024, 83: 2443. DOI: 10.1016/s0735-1097(24)04433-4.Peer-Reviewed Original ResearchBiometric contrastive learning for data-efficient deep learning from electrocardiographic images
Sangha V, Khunte A, Holste G, Mortazavi B, Wang Z, Oikonomou E, Khera R. Biometric contrastive learning for data-efficient deep learning from electrocardiographic images. Journal Of The American Medical Informatics Association 2024, 31: 855-865. PMID: 38269618, PMCID: PMC10990541, DOI: 10.1093/jamia/ocae002.Peer-Reviewed Original ResearchLabeled training dataContrastive learningECG imagesLabeled dataTraining dataDeep learningProportions of labeled dataArtificial intelligenceSelf-supervised contrastive learningTraditional supervised learningConvolutional neural networkHeld-out test setSupervised learningPretraining strategyBiometric signatureImageNet initializationPretraining approachNeural networkImageNetAI modelsImage objectsTest setLearningDetect atrial fibrillationEquivalent performance
News
News
- November 05, 2024
Yale Researchers at American Heart Association Scientific Session 2024
- August 06, 2024
Yale Researchers at European Society of Cardiology Conference 2024
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- November 20, 2023
Yale Researchers Wield AI for Heart Health