2017
Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases
Samuel VT, Shulman GI. Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. Cell Metabolism 2017, 27: 22-41. PMID: 28867301, PMCID: PMC5762395, DOI: 10.1016/j.cmet.2017.08.002.Peer-Reviewed Original ResearchConceptsInsulin resistanceNonalcoholic fatty liver diseaseFatty liver diseasePeripheral insulin resistanceHepatic insulin resistanceNew pharmacological strategiesHepatic complicationsBariatric surgeryLiver diseaseInsulin-stimulated glycogen synthesisHepatic diseasePharmacological strategiesNAFLDReceptor activationHepatic glucoseLipid metabolismInsulin receptor activationWeight lossEnergy expenditureHepatic diacylglycerolsGlycogen synthesisDiseaseLipid synthesisFlux of substratesComplicationsHepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans
Horst K, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ. Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. Cell Reports 2017, 19: 1997-2004. PMID: 28591572, PMCID: PMC5469939, DOI: 10.1016/j.celrep.2017.05.035.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceInsulin resistanceHepatic steatosisObese subjectsPKCε activationTissue-specific insulin sensitivityHepatic ceramide contentPeripheral insulin resistanceHepatic lipid accumulationPathogenesis of NAFLDLiver biopsyIntrahepatic triglyceridesLiver fatInsulin sensitivityAdipose tissueTranslational evidenceSteatosisLipid accumulationCeramide contentPKCε translocationSubjectsMolecular mechanismsDiacylglycerol contentHumansActivation
2009
Insulin Resistance
Samuel V, Petersen K, Shulman G. Insulin Resistance. 2009, 469-483. DOI: 10.1002/9780470747919.ch31.Peer-Reviewed Original ResearchInsulin-Sensitizing AgentsPeripheral insulin resistanceInsulin resistanceHepatic insulin resistanceSensitizing agentNAFLDHyperglycemiaFat