2020
Skin in the Game: Stem Cells in Repair, Cancer, and Homeostasis
Horsley V. Skin in the Game: Stem Cells in Repair, Cancer, and Homeostasis. Cell 2020, 181: 492-494. PMID: 32234524, DOI: 10.1016/j.cell.2020.03.019.Peer-Reviewed Original Research
2015
Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions
Stewart RM, Zubek AE, Rosowski KA, Schreiner SM, Horsley V, King MC. Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions. Journal Of Cell Biology 2015, 209: 403-418. PMID: 25963820, PMCID: PMC4427780, DOI: 10.1083/jcb.201502024.Peer-Reviewed Original ResearchConceptsIntercellular adhesionNuclear positionEpidermal tissue integrityLinker of nucleoskeletonCross talkPrimary mouse keratinocytesCytoskeleton (LINC) complexCytoplasmic cytoskeletonAdhesion functionMicrotubule networkDefective adhesionCytoskeletonSUN2Mouse keratinocytesTissue integrityFollicle structureEpidermal keratinocytesAdhesionNucleoskeletonCellsKeratinocytesAdhesion formationNucleusIntegrityComplexes
2013
Notch signaling represses p63 expression in the developing surface ectoderm
Tadeu AM, Horsley V. Notch signaling represses p63 expression in the developing surface ectoderm. Development 2013, 140: 3777-3786. PMID: 23924630, PMCID: PMC3754476, DOI: 10.1242/dev.093948.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell DifferentiationEctodermEmbryonic Stem CellsEpidermal CellsEpidermisGene Expression Regulation, DevelopmentalHumansKeratin-14KeratinocytesMiceModels, BiologicalPhosphoproteinsReceptors, NotchRepressor ProteinsSignal TransductionStem CellsTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsConceptsHuman embryonic stem cellsProgenitor cellsMouse embryosKeratinocyte lineageProgenitor cell specificationEmbryonic stem cellsNegative regulatory roleKeratinocyte fateCell specificationEctodermal specificationInhibition of NotchTranscriptional changesMolecular controlNotch signalingRegulatory roleSurface ectodermP63 expressionStem cellsCoordinated sequenceLineagesMature epidermisEmbryosKeratin 14ExpressionCells