An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling
Piersigilli F, Syed M, Lam TT, Dotta A, Massoud M, Vernocchi P, Quagliariello A, Putignani L, Auriti C, Salvatori G, Bagolan P, Bhandari V. An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling. Journal Of Perinatology 2020, 40: 952-961. PMID: 32080334, DOI: 10.1038/s41372-020-0623-3.Peer-Reviewed Original ResearchMeSH KeywordsGenomicsHernias, Diaphragmatic, CongenitalHumansInfant, NewbornLungMetabolomicsMicroRNAsPilot ProjectsConceptsCongenital diaphragmatic herniaCDH patientsTracheal aspiratesDiaphragmatic herniaAge-matched control patientsAge-matched controlsChromosomal microarray analysisControl patientsControl neonatesBlood samplesPatientsMiR expressionIncreased expressionPilot studyMiR-19bMiR-18MiR-20aMiR-16Genetic mutationsMetabolomic profilingHerniaMiR-17NeonatesMicroarray analysisMetabolic fingerprints