2021
Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension
Sitapara R, Lam TT, Gandjeva A, Tuder RM, Zisman LS. Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension. Pulmonary Circulation 2021, 11: 20458940211031109. PMID: 34966541, PMCID: PMC8711668, DOI: 10.1177/20458940211031109.Peer-Reviewed Original ResearchCyclin-dependent kinase 1Pulmonary arterial hypertensionProtein kinasePhosphoproteomic analysisIdiopathic PAHKinase 1Zinc finger transcription factorLung tissueFinger transcription factorCGMP-dependent protein kinase 1Casein kinase 2Regulation of BclMass spectrometry-based analysisProtein kinase 1Arterial hypertensionImmune regulationImportant regulatory roleIdiopathic pulmonary arterial hypertensionRhoGTPase signalingGSK3 alphaKinase networkPhosphorylation assaysTranscription factorsBioinformatics analysisGSK3 beta
2016
MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation
Mannam P, Rauniyar N, Lam TT, Luo R, Lee PJ, Srivastava A. MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation. Free Radical Biology And Medicine 2016, 101: 102-115. PMID: 27717867, DOI: 10.1016/j.freeradbiomed.2016.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCigarette SmokingGene Expression ProfilingGene Expression RegulationHumansInflammationInterleukin-1betaInterleukin-6MacrophagesMAP Kinase Kinase 3MiceMice, Inbred C57BLMice, KnockoutMitochondriaMitophagyNF-kappa BOxidative PhosphorylationPlant ExtractsPrimary Cell CulturePulmonary Disease, Chronic ObstructiveReactive Oxygen SpeciesTobaccoTumor Necrosis Factor-alphaConceptsCigarette smoke extractCigarette smokeCSE treatmentInflammatory responseLung tissueCigarette smoke-induced inflammationWild typeSerum pro-inflammatory cytokinesSmoke-induced inflammationProgression of COPDMitochondrial dysfunctionReactive oxygen speciesPro-inflammatory cytokinesInflammatory cytokine productionPrimary risk factorAssociated inflammatory responsePatient's lung tissueMouse lung tissueMitochondrial functionDual-specificity protein kinaseRespiratory capacitySpare respiratory capacityAirflow obstructionProtein kinase kinase 3CSE exposure