2023
Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association
Ardissino M, Morley A, Slob E, Schuermans A, Rayes B, Raisi-Estabragh Z, de Marvao A, Burgess S, Rogne T, Honigberg M, Ng F. Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. European Heart Journal 2023, 45: 443-454. PMID: 37738114, PMCID: PMC10849320, DOI: 10.1093/eurheartj/ehad631.Peer-Reviewed Original ResearchLow birth weightAdverse intrauterine environmentCoronary artery diseaseBirth weightIntrauterine environmentCardiac structureArtery diseaseFoetal effectsCardiovascular disease prevention strategiesDisease riskAdverse cardiac structureCardiovascular disease riskCommon pregnancy complicationLower stroke volumeDisease prevention strategiesMendelian randomization studyBenjamini-Hochberg correctionPregnancy complicationsIschemic strokeHeart failureAtrial fibrillationCardiometabolic diseasesIntrauterine influencesStroke volumeCardiovascular diseaseMendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia
Rogne T, DeWan A, Metayer C, Wiemels J, Ma X. Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101058. PMID: 37330008, DOI: 10.1016/j.ajogmf.2023.101058.Peer-Reviewed Original ResearchConceptsChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaMendelian randomization studyGestational ageLymphoblastic leukemiaRandomization studyBirthweightLeukemiaDyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibitionCirculating levels of micronutrients and risk of infections: a Mendelian randomization study
Flatby H, Ravi A, Damås J, Solligård E, Rogne T. Circulating levels of micronutrients and risk of infections: a Mendelian randomization study. BMC Medicine 2023, 21: 84. PMID: 36882828, PMCID: PMC9993583, DOI: 10.1186/s12916-023-02780-3.Peer-Reviewed Original ResearchConceptsRisk of infectionGastrointestinal infectionsBlood levelsMendelian randomizationMendelian randomization studyOdds ratioObservational studyImmune responseIndependent cohortRandomization studySignificant associationInfectionClear associationMR analysisLevels of micronutrientsStatistical significanceConclusionsOur resultsPrevious observational studiesStandard deviation increaseUK BiobankRiskLevels of copperEuropean ancestryAvailable summary statisticsAssociationSex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study
Ardissino M, Slob E, Carter P, Rogne T, Girling J, Burgess S, Ng F. Sex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study. Journal Of The American Heart Association 2023, 12: e027933. PMID: 36846989, PMCID: PMC10111460, DOI: 10.1161/jaha.122.027933.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseBody mass indexHeart failureCardiovascular diseaseReproductive factorsArtery diseaseIschemic strokeMass indexAtrial fibrillationLive birthsFirst birthCardiovascular disease riskType 2 diabetesBackground Observational studiesMendelian randomizationMendelian randomization studyModifiable mediatorsBlood pressureResidual confoundingObservational studyPrimary analysisRandomization studyDisease riskStrokeClinical interventionsDyslipidemia and risk of hypertensive disorders of pregnancy: a multi-ancestry Mendelian Randomization study
Hosier H, Lipkind H, DeWan A, Rogne T. Dyslipidemia and risk of hypertensive disorders of pregnancy: a multi-ancestry Mendelian Randomization study. American Journal Of Obstetrics And Gynecology 2023, 228: s141-s142. DOI: 10.1016/j.ajog.2022.11.280.Peer-Reviewed Original Research
2022
Impact of reproductive factors on major cardiovascular disease risk in women: a Mendelian randomization study
Ardissino M, Slob E, Rogne T, Burgess S, Ng F. Impact of reproductive factors on major cardiovascular disease risk in women: a Mendelian randomization study. European Heart Journal 2022, 43: ehac544.2500. DOI: 10.1093/eurheartj/ehac544.2500.Peer-Reviewed Original ResearchCoronary artery diseaseCardiovascular diseaseArtery diseaseHeart failureLive birthsIschemic strokeAtrial fibrillationRisk factorsFirst birthObservational studyReproductive factorsEarly menarcheReproductive historyFemale-specific risk factorsMajor cardiovascular disease riskSex-specific risk factorsBackground Cardiovascular diseaseCardiovascular disease riskMultiple observational studiesPrimary prevention measuresMendelian randomization studyEarly ageCardiovascular morbidityCardiovascular riskResidual confoundingIron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study
Mohus RM, Flatby H, Liyanarachi KV, DeWan AT, Solligård E, Damås JK, Åsvold BO, Gustad LT, Rogne T. Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study. Scientific Reports 2022, 12: 16157. PMID: 36171422, PMCID: PMC9516524, DOI: 10.1038/s41598-022-20679-6.Peer-Reviewed Original ResearchConceptsRisk of sepsisTwo-sample Mendelian randomization studyIron statusMendelian randomization studySerum ironOdds ratioCOVID-19Randomization studyTotal iron binding capacitySevere COVID-19Risk of hospitalizationHigh iron statusIron binding capacitySex-stratified analysesTransferrin saturationSevere infectionsIron biomarkersObservational studyHigh riskSepsisStandard deviation increaseHospitalizationFurther studiesRiskStatus
2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysis