2010
Mechanotransduction in the renal tubule
Weinbaum S, Duan Y, Satlin L, Wang T, Weinstein A. Mechanotransduction in the renal tubule. American Journal Of Physiology. Renal Physiology 2010, 299: f1220-f1236. PMID: 20810611, PMCID: PMC3006307, DOI: 10.1152/ajprenal.00453.2010.Peer-Reviewed Original ResearchConceptsCortical collecting ductCa(2+) signalingProximal tubulesModulation of Na(+Stretch-activated ion channelsDistal nephronRenal epitheliumWater reabsorptionRenal tubulesGlomerulotubular balanceInner earEndothelial cellsIon channelsHair cellsIntracellular signalingBone cellsCa(2TubulesPrimary ciliaIntracellular cytoskeletonCellsShear stressHydrodynamic forcesApical structuresFluid shear stress
2008
Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes
Duan Y, Gotoh N, Yan Q, Du Z, Weinstein A, Wang T, Weinbaum S. Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 11418-11423. PMID: 18685100, PMCID: PMC2516248, DOI: 10.1073/pnas.0804954105.Peer-Reviewed Original ResearchConceptsProximal tubule cellsAdherens junctionsTight junctionsEndothelial cellsEpithelial cellsMouse proximal tubule cellsCell actin cytoskeletonDistribution of filamentous actinActin cytoskeletal reorganizationStress fiber disruptionActin-disrupting drugsApical junctional complexRenal epithelial cellsPeripheral actin bandsCuboidal epithelial cellsVascular endothelial cellsActin cytoskeletonFilamentous actinCytoskeletal reorganizationCytoskeletal responsesF-actinTubule cellsRenal epitheliumCytochalasin D.Water reabsorptionThe olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration rate
Pluznick J, Zou D, Zhang X, Yan Q, Rodriguez‐Gil D, Eisner C, Wells E, Greer C, Schnermann J, Wang T, Firestein S, Caplan M. The olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration rate. The FASEB Journal 2008, 22: 761.12-761.12. DOI: 10.1096/fasebj.22.1_supplement.761.12.Peer-Reviewed Original ResearchGlomerular filtration rateMacula densaTubuloglomerular feedbackFiltration rateEfferent arteriolar diametersRT-PCRPlasma renin concentrationRenal function studiesAdenylyl cyclaseWild-type littermatesOlfactory G-proteinOlfactory receptorsRenin concentrationRenin secretionArteriolar diameterOlfactory adenylyl cyclaseWestern blotMouse kidneyKidneyNon-olfactory tissuesRenal epitheliumG proteinsFunction studiesMiceKey regulator