2016
Flow-activated proximal tubule function underlies glomerulotubular balance.
Du Z, Duan Y, Yan Q, Weinbaum S, Weinstein A, Wang T. Flow-activated proximal tubule function underlies glomerulotubular balance. 2016, 46: 105-117. PMID: 31105444, PMCID: PMC6519745.Peer-Reviewed Original ResearchProximal tubulesModulating Na<sup>+</sup>Isolated perfused proximal tubulesTubule cell volumeExchanger isoform 3Proximal tubule cellsProximal tubule functionPerfused proximal tubulesH-ATPase activityMouse tubulesNHE3 expressionStimulate sodiumApical membraneTubule functionBicarbonate absorptionTubule cellsReceptor-mediatedGlomerulotubular balanceMouse kidneyIsoform 3H-ATPaseCellular mechanismsTubulesTransporter densityNHE3
2012
Regulation of glomerulotubular balance. II. Impact of angiotensin II on flow-dependent transport
Du Z, Wan L, Yan Q, Weinbaum S, Weinstein A, Wang T. Regulation of glomerulotubular balance. II. Impact of angiotensin II on flow-dependent transport. American Journal Of Physiology. Renal Physiology 2012, 303: f1507-f1516. PMID: 22952281, PMCID: PMC3532483, DOI: 10.1152/ajprenal.00277.2012.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsBicarbonatesBiological TransportEnzyme InhibitorsFemaleHemostasisIn Vitro TechniquesKidney GlomerulusKidney TubulesLosartanMacrolidesMiceMice, KnockoutModels, AnimalProton-Translocating ATPasesReceptor, Angiotensin, Type 1SodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsNa(+)-H(+) exchanger 3Mouse tubulesImpact of angiotensin IIH-ATPaseMicroperfused in vitroAT(2) receptorsAT(1A) receptorFlow-mediated changesH-ATPase activityParacellular Cl(-Receptor availabilityAngiotensin IIAT(1ARegulate Na(+Increased Na(+Local angiotensinBasolateral transportJ(HCO3Mouse kidneyNet fluidInhibitor bafilomycinProtein levelsMiceReceptorsTubules
2007
Flow‐dependent transport in a mathematical model of rat proximal tubule
Weinstein A, Weinbaum S, Duan Y, Du Z, Yan Q, Wang T. Flow‐dependent transport in a mathematical model of rat proximal tubule. The FASEB Journal 2007, 21: a827-a828. DOI: 10.1096/fasebj.21.6.a827-d.Peer-Reviewed Original ResearchRat proximal tubulesNa+ reabsorptionProximal tubulesDiuretic effectModel tubuleOsmotic diuretic effectLow flowsSolute transportMouse tubulesLuminal perfusion rateNaCl reabsorptionPeritubular transportTranscellular NaCl reabsorptionCarbonic anhydrase inhibitionGlomerulotubular balanceTubulesReabsorptionTransporter densityLuminal flowMathematical modelRate of hydrationFlow-dependent transportInlet flowTransportTorque calculation