2008
Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes
Duan Y, Gotoh N, Yan Q, Du Z, Weinstein A, Wang T, Weinbaum S. Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 11418-11423. PMID: 18685100, PMCID: PMC2516248, DOI: 10.1073/pnas.0804954105.Peer-Reviewed Original ResearchConceptsProximal tubule cellsAdherens junctionsTight junctionsEndothelial cellsEpithelial cellsMouse proximal tubule cellsCell actin cytoskeletonDistribution of filamentous actinActin cytoskeletal reorganizationStress fiber disruptionActin-disrupting drugsApical junctional complexRenal epithelial cellsPeripheral actin bandsCuboidal epithelial cellsVascular endothelial cellsActin cytoskeletonFilamentous actinCytoskeletal reorganizationCytoskeletal responsesF-actinTubule cellsRenal epitheliumCytochalasin D.Water reabsorption
2007
Role of fluid shear stress in cytoskeleton reorganization of mouse proximal tubule epithelium
Duan Y, Du Z, Yan Q, Weinstein A, Weinbaum S, Wang T. Role of fluid shear stress in cytoskeleton reorganization of mouse proximal tubule epithelium. The FASEB Journal 2007, 21: a915-a915. DOI: 10.1096/fasebj.21.6.a915-a.Peer-Reviewed Original ResearchCytoskeleton reorganizationShear stressPeripheral actin networkCell-cell contactModulate cellular functionsTransmit mechanical forcesActin cytoskeletonActin networkCytoskeleton remodelingStress fibersF-actinCellular functionsVinculin expressionCytoskeletonZO-1Collagen substrateE-cadherinParallel plate flow chamberJunction-like structuresFluid shear stressShearFluid shearStrikingly different responsesCellsPT cells
2004
Mechanosensory function of microvilli of the kidney proximal tubule
Du Z, Duan Y, Yan Q, Weinstein A, Weinbaum S, Wang T. Mechanosensory function of microvilli of the kidney proximal tubule. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 13068-13073. PMID: 15319475, PMCID: PMC516518, DOI: 10.1073/pnas.0405179101.Peer-Reviewed Original ResearchConceptsKidney proximal tubulesProximal tubulesNa+ reabsorptionNa+ transportNa+-H+ exchange activityProximal tubule Na+ reabsorptionNa+-H+ exchangeLuminal cell membraneMechanosensory functionNa+ absorptionTubular diameterLuminal diameterMouse kidneyEpithelial microvilliReabsorptionTubulesKidneyAutoregulatory mechanismNa+ uptakeHormonal systemsMiceActin cytoskeletonCell membraneTerminal webBending moment