2007
Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response
Lin ZP, Zhu YL, Johnson DR, Rice KP, Nottoli T, Hains BC, McGrath J, Waxman SG, Sartorelli AC. Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response. Molecular Pharmacology 2007, 73: 243-251. PMID: 17959714, PMCID: PMC2780335, DOI: 10.1124/mol.107.039594.Peer-Reviewed Original ResearchConceptsNociceptive responsesPG synthesisInflammatory nociceptive responsesInflammatory pain thresholdWild-type miceCyclooxygenase-2 expressionMrp4 knockout miceMultidrug resistance protein 4Accumulation of intracellularMEF cellsMRP4 knockdownNucleotide agentsPain thresholdDisruptions of cAMPPGE metabolitePG levelsEnergy-dependent effluxProtein 4MiceMRP4PG transportIntracellular levelsProstaglandinsATP-binding cassette (ABC) familyPronounced reduction
2006
Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6
Jiang Z, Asplin JR, Evan AP, Rajendran VM, Velazquez H, Nottoli TP, Binder HJ, Aronson PS. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nature Genetics 2006, 38: 474-478. PMID: 16532010, DOI: 10.1038/ng1762.Peer-Reviewed Original ResearchConceptsCalcium oxalate urolithiasisOxalate urolithiasisPlasma oxalate concentrationIntestinal oxalate secretionUrinary oxalate concentrationCommon urologic diseaseNet intestinal absorptionAnion exchanger SLC26A6Dietary oxalate restrictionSlc26a6-null miceSignificant hyperoxaluriaOxalate restrictionUrologic diseasesHigh incidenceIntestinal absorptionExchanger SLC26A6Mutant miceUrolithiasisMiceMajor constitutive roleNet absorptionOxalate secretionHyperoxaluriaOxalate concentrationEpithelial tissues
2002
Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.
Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T. Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development 2002, 129: 2733-47. PMID: 12015300, DOI: 10.1242/dev.129.11.2733.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlastocystBreast NeoplasmsDNA-Binding ProteinsEmbryo ImplantationEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenotypeHumansMiceMice, KnockoutMorphogenesisPlacentaPolymerase Chain ReactionPregnancyRestriction MappingTranscription Factor AP-2Transcription FactorsConceptsExtra-embryonic lineagesAP-2gammaAnterior-posterior patterningStem cell maintenanceEarly postimplantation developmentExtra-embryonic tissuesAcid-responsive genesAP-2 familyRetinoic acid-responsive geneTrophoblast-specific expressionMaternal-embryonic interfaceMammalian developmentDays post coitumExtra-embryonic membranesCell maintenanceTranscription factorsEmbryonic developmentGene disruptionBiological functionsMouse embryosPostimplantation developmentPreimplantation embryosMutantsMolecular analysisNormal development
1999
AP-2αTranscription Factor Is Required for Early Morphogenesis of the Lens Vesicle
West-Mays J, Zhang J, Nottoli T, Hagopian-Donaldson S, Libby D, Strissel K, Williams T. AP-2αTranscription Factor Is Required for Early Morphogenesis of the Lens Vesicle. Developmental Biology 1999, 206: 46-62. PMID: 9918694, DOI: 10.1006/dbio.1998.9132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAquaporinsChimeraDNA-Binding ProteinsEyeEye ProteinsGene Expression Regulation, DevelopmentalHistocytochemistryHomeodomain ProteinsImmunohistochemistryLens, CrystallineMembrane GlycoproteinsMiceMice, KnockoutMorphogenesisPaired Box Transcription FactorsPAX6 Transcription FactorPhenotypeRepressor ProteinsTranscription Factor AP-2Transcription FactorsConceptsOcular defectsGanglion cell layerAP-2alphaRetinoic acid-responsive geneNeural retinaChimeric miceOcular tissuesOcular phenotypeDorsal retinalOptic cupCell layerLens vesicleAP-2 transcription factorsEyesEarly morphogenesisSurface ectodermLens developmentKnockout embryosCurrent studyAP-2 proteinsAcid-responsive genesExpression patternsPersistent adhesionTranscription factorsComplete lack
1998
AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice
Nottoli T, Hagopian-Donaldson S, Zhang J, Perkins A, Williams T. AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 13714-13719. PMID: 9811866, PMCID: PMC24885, DOI: 10.1073/pnas.95.23.13714.Peer-Reviewed Original ResearchConceptsAP-2Neural tubePleiotropic developmental abnormalitiesAP-2 geneCritical new roleLimb pattern formationRange of phenotypesBody wallLethal phenotypeKnockout miceMorphogenic pathwaysChimeric miceEye formationDevelopmental mechanismsHomozygous disruptionLimb duplicationsTeratogenic levelsDefective developmentDevelopmental abnormalitiesRetinoic acidPhenotypeMechanism of actionIndependent requirementsPattern formationChimeras