2024
Barriers to Effective Infection Prevention in the Neonatal Intensive Care Unit
Weser V, Crocker A, Murray T, Wright J, Truesdell E, Ciaburri R, Marks A, Martinello R, Hieftje K, Team H. Barriers to Effective Infection Prevention in the Neonatal Intensive Care Unit. Advances In Neonatal Care 2024, 24: 475-484. PMID: 39196970, DOI: 10.1097/anc.0000000000001195.Peer-Reviewed Original ResearchConceptsPatients' family membersInfection preventionFamily membersGroup of nursesReduce nurses’ burdenHand hygieneHospital-wide surveyIntensive care unitInductive content analysisDesign of educational interventionsCare unitNeonatal intensive care unitImprove patient outcomesEffective infection preventionHH educationNursing burdenEducational interventionFrontline staffHospital staffNeonatal nursesIP educationPatient's familyRisk of infection transmissionFocus groupsIP behavior
2023
Fighting the hidden pandemic of antimicrobial resistance in paediatrics: recommendations from the International Pediatric Association
Pana Z, El-Shabrawi M, Sultan M, Murray T, Alam A, Yewale V, Dharmapalan D, Klein J, Haddad J, Thacker N, Pulungan A, Hadjipanayis A. Fighting the hidden pandemic of antimicrobial resistance in paediatrics: recommendations from the International Pediatric Association. BMJ Paediatrics Open 2023, 7: e002084. PMID: 37500294, PMCID: PMC10387713, DOI: 10.1136/bmjpo-2023-002084.Peer-Reviewed Original ResearchReducing MRSA Infection in a New NICU During the COVID-19 Pandemic.
Barrett R, Fleiss N, Hansen C, Campbell M, Rychalsky M, Murdzek C, Krechevsky K, Abbott M, Allegra T, Blazevich B, Dunphy L, Fox A, Gambardella T, Garcia L, Grimm N, Scoffone A, Bizzarro M, Murray T. Reducing MRSA Infection in a New NICU During the COVID-19 Pandemic. Pediatrics 2023, 151 PMID: 36625072, DOI: 10.1542/peds.2022-057033.Peer-Reviewed Original ResearchConceptsInvasive MRSA infectionsInfection prevention strategiesMethicillin-resistant Staphylococcus aureusMRSA infectionOutcome measuresPrevention strategiesCOVID-19 pandemicMultidisciplinary quality improvement initiativeLevel IV NICUSubsequent invasive infectionsMRSA colonization rateCoronavirus disease 2019 (COVID-19) pandemicHealthcare Improvement's ModelQuality improvement initiativesDisease 2019 pandemicEffectiveness of interventionsPersonal protective equipmentSupply chain shortagesHospitalized neonatesInvasive infectionsPatient daysSkin colonizationHand hygieneMost NICUsNICU
2022
Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis
Öz H, Cheng E, Di Pietro C, Tebaldi T, Biancon G, Zeiss C, Zhang P, Huang P, Esquibies S, Britto C, Schupp J, Murray T, Halene S, Krause D, Egan M, Bruscia E. Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis. Cell Reports 2022, 41: 111797. PMID: 36516754, PMCID: PMC9833830, DOI: 10.1016/j.celrep.2022.111797.Peer-Reviewed Original ResearchConceptsC motif chemokine receptor 2Monocytes/macrophagesLung tissue damageCystic fibrosisTissue damageCF lungPulmonary neutrophilic inflammationPro-inflammatory environmentChemokine receptor 2CF lung diseaseNumber of monocytesSpecific therapeutic agentsGrowth factor βCF transmembrane conductance regulatorLung hyperinflammationLung neutrophiliaNeutrophilic inflammationNeutrophil inflammationInflammation contributesLung damageNeutrophil recruitmentLung diseaseLung tissueReceptor 2Therapeutic targetDisinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey Study
Roberts S, Havill N, Flores RM, Hendrix C, Williams MJ, Feinn RS, Choi SJ, Martinello RA, Marks AM, Murray TS. Disinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey Study. Journal Of Medical Internet Research 2022, 24: e42332. PMID: 36269222, PMCID: PMC9756115, DOI: 10.2196/42332.Peer-Reviewed Original ResearchPrevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 Pandemic
Elharake JA, Shafiq M, Cobanoglu A, Malik AA, Klotz M, Humphries JE, Murray T, Patel KM, Wilkinson D, Yildirim I, Diaz R, Rojas R, Cohen A, Lee A, Omer SB, Gilliam WS. Prevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 Pandemic. Preventing Chronic Disease 2022, 19: e61. PMID: 36137183, PMCID: PMC9541678, DOI: 10.5888/pcd19.220132.Peer-Reviewed Original ResearchConceptsPhysical health conditionsMental healthHealth conditionsChronic diseasesDepression ratesCOVID-19 pandemicSex/gender disparityPublic health officialsChildcare professionalsSevere asthmaHeart diseaseUS adultsAsthma ratesSociodemographic characteristicsHealth officialsDepressionDiseaseNational representativenessLinear regression modelsPrevalenceHealthRegression modelsPandemicProfessionalsGender disparitiesImplementation of Pre-Admission Caregiver Testing for COVID-19.
He M, Peaper DR, Murray T, Ciaburri R, Doyle J, Loyal J. Implementation of Pre-Admission Caregiver Testing for COVID-19. Hospital Pediatrics 2022, 12: e326-e329. PMID: 36047308, DOI: 10.1542/hpeds.2022-006715.Peer-Reviewed Original ResearchConceptsCOVID-19 testingPatient cohortingSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmissionBed capacityCohorting of patientsInpatient pediatric admissionsCoronavirus disease 2019 (COVID-19) transmissionTertiary children's hospitalPediatric emergency departmentCOVID-19 positivityCOVID-19Procedural admissionsIsolation precautionsAsymptomatic adultsNegative childrenOverall incidencePediatric admissionsChildren's HospitalEmergency departmentHospitalized childrenDirect admissionInfection preventionOverall bed capacityInpatient unitPositive testRelationship between the use of nonpharmaceutical interventions and COVID-19 vaccination among U.S. child care providers: A prospective cohort study
Patel KM, Shafiq M, Malik AA, Cobanoglu A, Klotz M, Eric Humphries J, Lee A, Murray T, Wilkinson D, Yildirim I, Elharake JA, Diaz R, Rojas R, Kuperwajs Cohen A, Omer SB, Gilliam WS. Relationship between the use of nonpharmaceutical interventions and COVID-19 vaccination among U.S. child care providers: A prospective cohort study. Vaccine 2022, 40: 4098-4104. PMID: 35660329, PMCID: PMC9135692, DOI: 10.1016/j.vaccine.2022.05.064.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationProspective cohort studyCare providersNonpharmaceutical interventionsChild care providersCohort studyLikelihood of vaccinationPreventative health behaviorsVaccinationHealth behaviorsCare programMandatory vaccinationSignificant associationVaccine mandatesDistrict of ColumbiaLarge healthInterventionPandemic controlCOVID-19Child care programsProvidersEmail surveyNonadherenceMeasuresA mixed-methods evaluation on the efficacy and perceptions of needleless connector disinfectants
Roberts SC, Hendrix CA, Edwards LM, Feinn RS, Martinello RA, Murray TS. A mixed-methods evaluation on the efficacy and perceptions of needleless connector disinfectants. Infection Control And Hospital Epidemiology 2022, 44: 230-233. PMID: 35387702, PMCID: PMC9929708, DOI: 10.1017/ice.2022.72.Peer-Reviewed Original ResearchConceptsNeedleless connectorsMixed-methods evaluationNursing staffOverall bacterial burdenBloodstream infection preventionAcademic tertiary hospitalIsopropyl alcohol wipesSterile water controlTertiary hospitalNursing assessmentBacterial burdenInfection preventionImproved complianceStaff complianceChlorhexidine gluconateScrub timeConvenience sampleAlcohol wipesStaphylococcus epidermidisEfficacyProduct efficacyDry timeWipesDisinfection practicesComplianceBacterial Surface Detachment during Nebulization with Contaminated Reusable Home Nebulizers
Harris JC, Collins MS, Huang PH, Schramm CM, Nero T, Yan J, Murray TS. Bacterial Surface Detachment during Nebulization with Contaminated Reusable Home Nebulizers. Microbiology Spectrum 2022, 10: e02535-21. PMID: 35107362, PMCID: PMC8809330, DOI: 10.1128/spectrum.02535-21.Peer-Reviewed Original ResearchConceptsAlbuterol nebulizationNebulized therapyHome nebulizersCystic fibrosisChronic respiratory diseasesAerosolized medicationsLung infectionCF patientsRespiratory diseasePathogenic bacteriaPatientsNext Generation ImpactorClinical isolatesMedicationsLungPari LCTherapyAnonymous patientsClinical bacteriaNebulizationNebulizerAerosolizationPathogenic microbesDetachmentSubset of bacteriaAssociation of Child Masking With COVID-19–Related Closures in US Childcare Programs
Murray TS, Malik AA, Shafiq M, Lee A, Harris C, Klotz M, Humphries JE, Patel KM, Wilkinson D, Yildirim I, Elharake JA, Diaz R, Reyes C, Omer SB, Gilliam WS. Association of Child Masking With COVID-19–Related Closures in US Childcare Programs. JAMA Network Open 2022, 5: e2141227. PMID: 35084484, PMCID: PMC8796014, DOI: 10.1001/jamanetworkopen.2021.41227.Peer-Reviewed Original ResearchConceptsCOVID-19 casesLower riskImportant public health policy implicationsCOVID-19-related closuresPublic health policy implicationsChildren 2 yearsElectronic survey studyCenter-based childcare programsHealth policy implicationsSARS-CoV-2Survey studyChildcare professionalsMAIN OUTCOMEProgram closureHealth policyStudy periodRobust SEsBaselineChildcare programsCOVID-19Young childrenChildcare settingsChildrenPhysical distancingAssociation
2021
COVID-19 Vaccine Uptake Among US Child Care Providers
Patel KM, Malik AA, Lee A, Klotz M, Humphries JE, Murray T, Wilkinson D, Shafiq M, Yildirim I, Elharake JA, Diaz R, Reyes C, Omer SB, Gilliam WS. COVID-19 Vaccine Uptake Among US Child Care Providers. Pediatrics 2021, 148: e2021053813. PMID: 34452977, PMCID: PMC9277775, DOI: 10.1542/peds.2021-053813.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccine uptakeVaccine uptakeCare providersChild care providersVaccination ratesSevere acute respiratory syndrome coronavirus 2Adult populationState public health leadersUS general adult populationAcute respiratory syndrome coronavirus 2General US adult populationRespiratory syndrome coronavirus 2Home-based child care programsSyndrome coronavirus 2US adult populationGeneral adult populationCross-sectional surveyPublic health implicationsPublic health leadersAnnual household incomeCoronavirus 2Care settingsInclusion criteriaCare programChild care settingsMass severe acute respiratory coronavirus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel – ERRATUM
Roberts SC, Peaper DR, Thorne CD, Sussman LS, Murray TS, Choi SJ, Pettker CM, Russi MB, Martinello RA. Mass severe acute respiratory coronavirus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel – ERRATUM. Infection Control And Hospital Epidemiology 2021, 43: 1312-1312. PMID: 33779533, PMCID: PMC9981472, DOI: 10.1017/ice.2021.107.Peer-Reviewed Original ResearchMass severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel
Roberts SC, Peaper DR, Thorne CD, Sussman LS, Murray TS, Choi SJ, Pettker CM, Russi MB, Martinello RA. Mass severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel. Infection Control And Hospital Epidemiology 2021, 42: 1-2. PMID: 33487206, PMCID: PMC7853752, DOI: 10.1017/ice.2021.9.Peer-Reviewed Original ResearchCOVID-19 Transmission in US Child Care Programs
Gilliam WS, Malik AA, Shafiq M, Klotz M, Reyes C, Humphries JE, Murray T, Elharake JA, Wilkinson D, Omer SB. COVID-19 Transmission in US Child Care Programs. Pediatrics 2021, 147: e2020031971. PMID: 33055228, DOI: 10.1542/peds.2020-031971.Peer-Reviewed Original ResearchConceptsCare programCOVID-19 transmissionCare providersCOVID-19Child care programsChild care providersPropensity score-matched case-control analysisCOVID-19 outcomesLogistic regression analysisCase-control analysisUS COVID-19 pandemicChild carePotential confoundersElevated riskHome-based providersCareUS pandemicRegression analysisCOVID-19 pandemicDegree of exposureExposureMonthsOutcomesEarly monthsProviders
2020
Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children in a Large Regional US Health System During the Coronavirus Disease 2019 Pandemic.
Peaper DR, Murdzek C, Oliveira CR, Murray TS. Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children in a Large Regional US Health System During the Coronavirus Disease 2019 Pandemic. The Pediatric Infectious Disease Journal 2020, 40: 175-181. PMID: 33399431, PMCID: PMC8852689, DOI: 10.1097/inf.0000000000003024.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Subset of childrenPediatric casesHealth systemCycle threshold valuesCoronavirus 2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNACross-sectional time-series studyCoronavirus disease 2019 (COVID-19) testingPositive pediatric casesSimilar cycle threshold valuesCoronavirus disease 2019 (COVID-19) pandemicUpper respiratory tractCoronavirus disease 2019Large health systemYears of ageDisease 2019 pandemicUS health systemAmbulatory locationsVirology resultsAsymptomatic childrenUnmasking symptomatic dermatographism in the time of COVID-19
Wong KH, Murray T, Osborn R, Soffer GK. Unmasking symptomatic dermatographism in the time of COVID-19. Postgraduate Medical Journal 2020, 97: 402-402. PMID: 32913035, PMCID: PMC10016992, DOI: 10.1136/postgradmedj-2020-138688.Peer-Reviewed Case Reports and Technical NotesOxygen nipple and nut (Christmas tree) adaptor contamination rates and decontamination with disinfecting wipes
Colandrea NA, Cleary ML, Peaper DR, Sullivan LK, Martinello RA, Murray TS. Oxygen nipple and nut (Christmas tree) adaptor contamination rates and decontamination with disinfecting wipes. Infection Control And Hospital Epidemiology 2020, 41: 396-399. PMID: 31983357, DOI: 10.1017/ice.2020.9.Peer-Reviewed Original Research
2019
Shifting focus toward healthcare-associated bloodstream infections: The need for neonatal intensive care unit–specific NHSN definitions
Advani SD, Murray TS, Murdzek CM, Aniskiewicz MJ, Bizzarro MJ. Shifting focus toward healthcare-associated bloodstream infections: The need for neonatal intensive care unit–specific NHSN definitions. Infection Control And Hospital Epidemiology 2019, 41: 181-186. PMID: 31694731, DOI: 10.1017/ice.2019.310.Peer-Reviewed Original ResearchConceptsBloodstream infectionsNHSN definitionsNICU populationSite-specific definitionClinical definitionNational Healthcare Safety Network definitionsNeonatal intensive care unit populationIntensive care unit populationHealthcare-associated bloodstream infectionsYale-New Haven Children's HospitalLevel IV NICUSafety Network definitionsDirect prevention effortsMcNemar χ2 testSource of infectionGut translocationPreterm neonatesRespiratory supportPremature infantsRetrospective reviewChildren's HospitalPatient daysIncidence rateNICU teamUnit populationNebulizer cleaning and disinfection practices in families with cystic fibrosis: The relationship between attitudes, practice and microbe colonization
Murray TS, O'Rourke TK, Feinn R, Drapeau G, Collins MS. Nebulizer cleaning and disinfection practices in families with cystic fibrosis: The relationship between attitudes, practice and microbe colonization. Journal Of Cystic Fibrosis 2019, 18: 823-828. PMID: 31126899, DOI: 10.1016/j.jcf.2019.05.008.Peer-Reviewed Original ResearchConceptsInfection control practicesInfection preventionCystic fibrosisHome respiratory equipmentComplexity of careHome health careInfection control behaviorsControl practicesRespiratory equipmentHome nebulizersNew educational interventionDaily burdenHealth maintenanceLung pathogensEducation interventionRecovery of organismsEducational interventionHealth carePreventionMicrobe colonizationCareDisinfection practicesFibrosisFrequency of disinfectionSubset of families