2024
Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participants
2023
Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses
Renedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.Peer-Reviewed Original ResearchMeSH KeywordsHemorrhagic StrokeHospitalsHumansPopulation HealthRetrospective StudiesRisk FactorsStrokeConceptsHospital Frailty Risk ScoreRisk of strokeHighest Hospital Frailty Risk ScoresDate of consentFrailty Risk ScoreMendelian randomization analysisStroke riskRisk scoreRandomization analysisTime of enrollmentAvailable electronic health recordsMendelian randomizationElectronic health recordsLook-back periodIncident strokeDose-response wayFrailty statusHemorrhagic strokeMultivariable analysisStroke eventsObservational studyHigh riskFrailtySignificant associationSimilar associationPerformance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol useAssessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlcoholismCohort StudiesFractures, BoneFrailtyHIV InfectionsHumansRisk FactorsConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codes
2022
Factors Associated With Days Away From Home in the Year After Major Surgery Among Community-living Older Persons
Gill TM, Becher RD, Murphy TE, Gahbauer EA, Leo-Summers L, Han L. Factors Associated With Days Away From Home in the Year After Major Surgery Among Community-living Older Persons. Annals Of Surgery 2022, 278: e13-e19. PMID: 35837967, PMCID: PMC9840715, DOI: 10.1097/sla.0000000000005528.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overHospitalizationHospitalsHumansPatient DischargeQuality of LifeRisk FactorsConceptsHealth care facilitiesMajor surgeryAge 85 yearsCare facilitiesOlder personsRisk factorsNumber of daysLower peak expiratory flowCommunity-living older personsShort Physical Performance BatteryIndependent risk factorCommunity-living personsPhysical Performance BatteryPeak expiratory flowCandidate risk factorsQuality of lifeHospital dischargeMultivariable analysisExpiratory flowMedian numberPerformance BatteryMusculoskeletal surgerySurgeryMean differenceHospital
2020
Functional Effects of Intervening Illnesses and Injuries After Hospitalization for Major Surgery in Community-living Older Persons
Gill TM, Han L, Gahbauer EA, Leo-Summers L, Murphy TE, Becher RD. Functional Effects of Intervening Illnesses and Injuries After Hospitalization for Major Surgery in Community-living Older Persons. Annals Of Surgery 2020, 273: 834-841. PMID: 33074902, PMCID: PMC8370041, DOI: 10.1097/sla.0000000000004438.Peer-Reviewed Original ResearchConceptsMajor surgeryED visitsRestricted activityFunctional statusFunctional declineOlder personsCommunity-living older personsAdjusted hazard ratioAdverse functional outcomesCommunity-living personsEmergency department visitsTraditional risk factorsCorresponding odds ratiosFunctional effectsIllness/injuryHazard ratioDepartment visitsFunctional recoveryFunctional outcomeRisk factorsOdds ratioHospitalizationSurgeryInjuryVisitsA Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent rates
2017
Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study
Cochrane S, Chen S, Fitzgerald J, Dodson J, Fielding R, King A, McDermott M, Manini T, Marsh A, Newman A, Pahor M, Tudor‐Locke C, Ambrosius W, Buford T, Espeland M, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Pierce J, Romashkan S, Patel K, Bonds D, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Butitta B, Donatto S, Cocreham S, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Anton S, Nayfield S, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer‐Skinner R, Wrights A, Fries R, Barr D, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Handberg E, Flynn G, Gill T, Hankinson J, Fragoso C, Kaplan R. Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study. Journal Of The American Heart Association 2017, 6: e007215. PMID: 29197830, PMCID: PMC5779035, DOI: 10.1161/jaha.117.007215.Peer-Reviewed Original ResearchMeSH KeywordsActigraphyAge FactorsAgedAged, 80 and overAgingCardiovascular DiseasesExerciseExercise TherapyFemaleFitness TrackersGeriatric AssessmentHealth Knowledge, Attitudes, PracticeHumansIncidenceMaleMobility LimitationPatient Education as TopicPredictive Value of TestsPrognosisProtective FactorsRisk FactorsRisk Reduction BehaviorTime FactorsUnited StatesConceptsCardiovascular eventsPhysical activityOlder adultsLower incidenceLower cardiovascular event ratesCardiovascular event ratesCardiovascular risk factorsSubsequent cardiovascular eventsMedical record reviewHealth education interventionHip-worn accelerometersPhysical activity surveillanceLife Study participantsMonths postrandomizationLife studiesRecord reviewRisk factorsDaily PAStudy participantsEvent ratesMobility limitationsEducation interventionLongitudinal associationsBaselineActivity surveillance
2016
Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study
Aubertin-Leheudre M, Anton S, Beavers D, Manini T, Fielding R, Newman A, Church T, Kritchevsky S, Conroy D, McDermott M, Botoseneanu A, Hauser M, Pahor M, Gill T, Fragoso C, Fielding R, Hauser M, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler M, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Pahor M, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rush J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Sink K, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Gill T, Hankinson J, Fragoso C, Groessl E, Kaplan R. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. Journal Of The American Medical Directors Association 2016, 18: 312-319. PMID: 27914851, PMCID: PMC5366275, DOI: 10.1016/j.jamda.2016.10.001.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureBlood pressureOlder adultsWaist circumferenceRisk factorsMetabolic disease risk factorsHigher diastolic blood pressureAbdominal obesity criteriaObese older adultsMetabolic risk factorsMetabolic syndrome criteriaDisease risk factorsBody mass indexCardiometabolic disease riskPresence of dynapeniaAged 70Obesity criteriaSyndrome criteriaLifestyle interventionMetS criteriaBlood lipidsObese groupMass indexObesity statusMetabolic healthSex Differences in Concomitant Trajectories of Self-Reported Disability and Measured Physical Capacity in Older Adults
Botoseneanu A, Allore HG, de Leon C, Gahbauer EA, Gill TM. Sex Differences in Concomitant Trajectories of Self-Reported Disability and Measured Physical Capacity in Older Adults. The Journals Of Gerontology Series A 2016, 71: 1056-1062. PMID: 27071781, PMCID: PMC4945890, DOI: 10.1093/gerona/glw038.Peer-Reviewed Original ResearchConceptsSelf-reported disabilityShort Physical Performance Battery scorePhysical Performance Battery scoreGrip strengthPhysical capacityFunctional statusBattery scoreShort Physical Performance BatterySelf-reported functional statusChronic disease statusPhysical Performance BatteryWeak grip strengthPrecipitating Events ProjectHealth risk factorsSex-specific comparisonsAge-related declineFunctional indicatorsDisability ScaleRisk factorsOlder womenPerformance BatterySociodemographic characteristicsOlder adultsDisabilityWomen
2015
Aging-Related Considerations When Evaluating the Forced Expiratory Volume in 1 Second (FEV1) Over Time
Fragoso C, McAvay G, Van Ness PH, Metter EJ, Ferrucci L, Yaggi HK, Concato J, Gill TM. Aging-Related Considerations When Evaluating the Forced Expiratory Volume in 1 Second (FEV1) Over Time. The Journals Of Gerontology Series A 2015, 71: 929-934. PMID: 26525091, PMCID: PMC4906321, DOI: 10.1093/gerona/glv201.Peer-Reviewed Original ResearchAgedAgingBronchitis, ChronicDisease ProgressionFemaleForced Expiratory VolumeHealth Status DisparitiesHumansLongitudinal StudiesMaleMiddle AgedMyocardial InfarctionObesityPredictive Value of TestsResearch DesignRespiratory Function TestsRespiratory InsufficiencyRisk FactorsSmokingTime FactorsUnited StatesFunctional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilation
2012
Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons.
Gill TM, Gahbauer EA, Murphy TE, Han L, Allore HG. Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons. Annals Of Internal Medicine 2012, 156: 131-40. PMID: 22250144, PMCID: PMC3278794, DOI: 10.7326/0003-4819-156-2-201201170-00009.Peer-Reviewed Original ResearchConceptsLong-term disabilityRisk factorsOlder personsCohort studyCommunity mobilityShort Physical Performance BatteryMultivariate hazard ratiosProspective cohort studyPhysical Performance BatteryMultiple risk factorsCandidate risk factorsSpecific risk factorsNational InstituteLong-term mobility disabilityHazard ratioAbsolute riskPerformance BatteryPotential precipitantsMobility disabilityRestricted activityOlder ageObserved associationsInitial onsetStrong associationQuarter mile
2001
Restricted activity among community-living older persons: incidence, precipitants, and health care utilization.
Gill T, Desai M, Gahbauer E, Holford T, Williams C. Restricted activity among community-living older persons: incidence, precipitants, and health care utilization. Annals Of Internal Medicine 2001, 135: 313-21. PMID: 11529694, DOI: 10.7326/0003-4819-135-5-200109040-00007.Peer-Reviewed Original ResearchConceptsCommunity-living older personsHealth care utilizationCare utilizationRestricted activityOlder personsProspective cohort studyEmergency department visitsMonthly telephone interviewsPhysician office visitsLarge health planYears of ageHealth-related problemsCohort studyDepartment visitsHospital admissionOffice visitsFunctional statusMedical attentionHigh riskHealth plansTelephone interviewsMonthsConsecutive monthsEpisodesDisabilityScreening Mammography: Is It Suitably Targeted to Older Women Who are Most Likely to Benefit?
Scinto J, Gill T, Grady J, Holmboe E. Screening Mammography: Is It Suitably Targeted to Older Women Who are Most Likely to Benefit? Journal Of The American Geriatrics Society 2001, 49: 1101-1104. PMID: 11555074, DOI: 10.1046/j.1532-5415.2001.49216.x.Peer-Reviewed Original ResearchConceptsOlder womenPrognostic groupsPrognostic stageMammography useCommunity-dwelling older womenFavorable prognostic groupFive-year mortalityProspective cohort studyWorst prognostic groupMammography use ratesCause mortalityCohort studyElderly ProgramEpidemiologic studiesNew Haven CountyMedicare Part BScreening mammographyWomenMortalityMortality indexMammographyUse ratesNew HavenMammogramsPart BThe Culmulative Effects of Social Class on Mental Status Decline
Long J, Ickovics J, Gill T, Horwitz R, Gill T, Horwitz R. The Culmulative Effects of Social Class on Mental Status Decline. Journal Of The American Geriatrics Society 2001, 49: 1005-1007. PMID: 11527501, DOI: 10.1046/j.1532-5415.2001.49198.x.Peer-Reviewed Original Research
2000
Dizziness among older adults: a possible geriatric syndrome.
Tinetti M, Williams C, Gill T. Dizziness among older adults: a possible geriatric syndrome. Annals Of Internal Medicine 2000, 132: 337-44. PMID: 10691583, DOI: 10.7326/0003-4819-132-5-200003070-00002.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnxietyConnecticutCross-Sectional StudiesDepressionDizzinessDrug-Related Side Effects and Adverse ReactionsFemaleHearing DisordersHumansHypotension, OrthostaticMaleMyocardial InfarctionPostural BalancePrevalenceRisk FactorsSensation DisordersStatistics as TopicSyndromeConceptsAdjusted relative riskGeriatric syndromesRelative riskEpisodes of dizzinessCommunity-living personsPast myocardial infarctionCross-sectional studyYears of agePostural hypotensionMore medicationsMyocardial infarctionImpaired balanceDizzinessDepressive symptomsSyndromeImpaired hearingSpecific causesOlder adultsMultiple causesSymptomsProbability sampleRiskSensationCauseNew Haven
1997
The Role of Change in Physical Performance in Determining Risk for Dependence in Activities of Daily Living Among Nondisabled Community-Living Elderly Persons
Gill T, Williams C, de Leon C, Tinetti M. The Role of Change in Physical Performance in Determining Risk for Dependence in Activities of Daily Living Among Nondisabled Community-Living Elderly Persons. Journal Of Clinical Epidemiology 1997, 50: 765-772. PMID: 9253386, DOI: 10.1016/s0895-4356(97)00065-6.Peer-Reviewed Original ResearchConceptsUseful prognostic informationADL dependencePhysical performanceElderly personsPrognostic informationDaily livingCommunity-living elderly personsSingle assessmentLarge representative cohortAssessment of changesFuture disabilityBaseline interviewRepresentative cohortPowerful predictorRole of changesRiskParticipantsShort intervalsYearsAssessmentBaseline performancePersonsCohortYear interviewsADL
1995
Assessing Risk for the Onset of Functional Dependence Among Older Adults: The Role of Physical Performance
Gill T, Williams C, Tinetti M. Assessing Risk for the Onset of Functional Dependence Among Older Adults: The Role of Physical Performance. Journal Of The American Geriatrics Society 1995, 43: 603-609. PMID: 7775716, DOI: 10.1111/j.1532-5415.1995.tb07192.x.Peer-Reviewed Original ResearchConceptsCommunity-dwelling adultsBasic ADLPhysical performanceOlder adultsMain outcome eventTimed testsPhysical performance testsChair standNew disabilityBaseline interviewOutcome eventsCohort membersDaily livingHigh riskRepresentative cohortRate of dependenceOlder personsRisk assessment strategiesADLRapid gaitBasic activitiesComplete dataAdultsRiskOnsetEvaluating the efficacy of cancer screening: Clinical distinctions and case-control studies
Gill T, Horwitz R. Evaluating the efficacy of cancer screening: Clinical distinctions and case-control studies. Journal Of Clinical Epidemiology 1995, 48: 281-292. PMID: 7869074, DOI: 10.1016/0895-4356(94)00129-e.Peer-Reviewed Original ResearchConceptsCase-control studyBaseline risk factorsCancer screeningRisk factorsClinical distinctionAttribution of deathImportant clinical distinctionDeath of patientsCase-control approachSufficient followPatient managementHealth policyConfidence intervalsEfficacyPatientsEfficient alternative designsDeathScreeningInvestigatorsFollowCancerStudyCliniciansDiseaseTrials