2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcome
2023
Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study
Cao X, Li X, Zhang J, Sun X, Yang G, Zhao Y, Li S, Hoogendijk E, Wang X, Zhu Y, Allore H, Gill T, Liu Z. Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study. JMIR Public Health And Surveillance 2023, 9: e45502. PMID: 37200070, PMCID: PMC10236284, DOI: 10.2196/45502.Peer-Reviewed Original ResearchConceptsMultiple adverse outcomesChronic kidney diseaseDiabetes-related microvascular diseaseAdverse outcomesCause mortalityCardiovascular diseaseMiddle-aged adultsUK Biobank participantsHigh riskMicrovascular diseaseEye diseaseIncident type 2 diabetes mellitusType 2 diabetes mellitusProportional hazards regression modelsBiobank participantsMultivariable-adjusted modelsProspective cohort studyHazards regression modelsNormal glucose metabolismDiabetes-related burdenDiabetes-related diseasesHealth care resourcesNonfrail counterpartsFrailty assessmentCohort studyAssociation of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study
Cao X, Yang Z, Li X, Chen C, Hoogendijk E, Zhang J, Yao N, Ma L, Zhang Y, Zhu Y, Zhang X, Du Y, Wang X, Wu X, Gill T, Liu Z. Association of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study. BMC Medicine 2023, 21: 74. PMID: 36829175, PMCID: PMC9951842, DOI: 10.1186/s12916-023-02774-1.Peer-Reviewed Original ResearchConceptsLong-term cancer survivorsType 2 diabetes mellitusCancer survivorsCardiovascular diseaseIncidence riskDiabetes mellitusFrailty IndicatorCox proportional hazards regression modelRisk of CVDProportional hazards regression modelsNon-frail participantsSerious healthcare burdenIncident cardiovascular diseaseMultivariable-adjusted modelsProspective cohort studyAssociation of frailtyPrimary care dataHazards regression modelsTime of recruitmentQuality of lifeLater comorbidityIncident T2DMCohort studyFrailty phenotypeFrailty index
2018
Functional Trajectories Before and After Major Surgery in Older Adults
Stabenau HF, Becher RD, Gahbauer EA, Leo-Summers L, Allore HG, Gill TM. Functional Trajectories Before and After Major Surgery in Older Adults. Annals Of Surgery 2018, 268: 911-917. PMID: 29356710, PMCID: PMC6521949, DOI: 10.1097/sla.0000000000002659.Peer-Reviewed Original ResearchConceptsMajor surgeryNonelective surgeryFunctional trajectoriesSevere disabilityOlder adultsCourse of disabilityFirst major surgeryPersons 70 yearsProspective cohort studyCohort studyFunctional prognosisModerate disabilityPartial improvementSurgeryPremorbid functionOlder personsStudy periodAnalytic sampleLittle improvementRapid improvementTrajectory groupsMild disabilityMost participantsDisabilityGradual improvement
2015
The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people
Gill TM, Gahbauer EA, Han L, Allore HG. The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. The BMJ 2015, 350: h2361. PMID: 25995357, PMCID: PMC4443433, DOI: 10.1136/bmj.h2361.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCohort StudiesConnecticutDementiaDisability EvaluationDisabled PersonsDisease ProgressionFemaleFrail ElderlyGeriatric AssessmentHospitalizationHumansMaleMultiple Organ FailureNeoplasmsPrognosisProspective StudiesSeverity of Illness IndexTerminal CareUnited StatesConceptsCourse of disabilityProspective cohort studyHospital admissionTrajectories of disabilitySeverity of disabilityCatastrophic disabilitySevere disabilityCohort studyAcute hospital admissionPalliative care approachMultiple hospital admissionsAdvance care planningPersonal care needsEnd of lifeDisability scoresOlder patientsPotential confoundersOccurrence of admissionMultivariable modelCare planningMAIN OUTCOMECare approachDaily livingCare needsAdmissionFunctional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilation
2012
Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons.
Gill TM, Gahbauer EA, Murphy TE, Han L, Allore HG. Risk factors and precipitants of long-term disability in community mobility: a cohort study of older persons. Annals Of Internal Medicine 2012, 156: 131-40. PMID: 22250144, PMCID: PMC3278794, DOI: 10.7326/0003-4819-156-2-201201170-00009.Peer-Reviewed Original ResearchConceptsLong-term disabilityRisk factorsOlder personsCohort studyCommunity mobilityShort Physical Performance BatteryMultivariate hazard ratiosProspective cohort studyPhysical Performance BatteryMultiple risk factorsCandidate risk factorsSpecific risk factorsNational InstituteLong-term mobility disabilityHazard ratioAbsolute riskPerformance BatteryPotential precipitantsMobility disabilityRestricted activityOlder ageObserved associationsInitial onsetStrong associationQuarter mile
2010
Change in Disability After Hospitalization or Restricted Activity in Older Persons
Gill TM, Allore HG, Gahbauer EA, Murphy TE. Change in Disability After Hospitalization or Restricted Activity in Older Persons. JAMA 2010, 304: 1919-1928. PMID: 21045098, PMCID: PMC3124926, DOI: 10.1001/jama.2010.1568.Peer-Reviewed Original ResearchConceptsHazard ratioPhysical frailtySevere disabilityOlder personsMild disabilityMultivariable hazard ratiosProspective cohort studyCommunity-living personsFall-related injuriesGreater New HavenState of disabilityLikelihood of recoveryCohort studyAbsolute riskFrail individualsHospitalizationDaily livingNonfrail individualsRestricted activityInjuryTelephone interviewsFrailtyIllnessMonthsDisability
2004
Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons
Gill TM, Allore HG, Holford TR, Guo Z. Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons. JAMA 2004, 292: 2115-2124. PMID: 15523072, DOI: 10.1001/jama.292.17.2115.Peer-Reviewed Original ResearchConceptsDevelopment of disabilityPhysical frailtyRestricted activityDaily livingOlder personsProspective cohort studyMonthly telephone interviewsMonths of hospitalizationPopulation attributable fractionGreater New HavenPrevention of disabilityOccurrence of disabilityCohort studyFrail participantsHospital admissionNonfrail participantsMultivariable hazardMAIN OUTCOMEDisabling processHospitalizationTelephone interviewsDisability onsetGeneral communityOlder adultsFrailtyRecovery From Disability Among Community-Dwelling Older Persons
Hardy SE, Gill TM. Recovery From Disability Among Community-Dwelling Older Persons. JAMA 2004, 291: 1596-1602. PMID: 15069047, DOI: 10.1001/jama.291.13.1596.Peer-Reviewed Original ResearchConceptsOlder personsADL functionCommunity-dwelling older personsProspective cohort studyMonthly telephone interviewsCommunity-dwelling personsHigh-risk groupDuration of disabilityDuration of recoveryCourse of recoveryLikelihood of recoveryDisability episodeCohort studyMajority of participantsTrue incidenceChronic conditionsPhysical frailtyDaily livingDemographic featuresCognitive functionTelephone interviewsMonthsMonthly assessmentsPertinent subgroupsDisability
2001
Restricted activity among community-living older persons: incidence, precipitants, and health care utilization.
Gill T, Desai M, Gahbauer E, Holford T, Williams C. Restricted activity among community-living older persons: incidence, precipitants, and health care utilization. Annals Of Internal Medicine 2001, 135: 313-21. PMID: 11529694, DOI: 10.7326/0003-4819-135-5-200109040-00007.Peer-Reviewed Original ResearchConceptsCommunity-living older personsHealth care utilizationCare utilizationRestricted activityOlder personsProspective cohort studyEmergency department visitsMonthly telephone interviewsPhysician office visitsLarge health planYears of ageHealth-related problemsCohort studyDepartment visitsHospital admissionOffice visitsFunctional statusMedical attentionHigh riskHealth plansTelephone interviewsMonthsConsecutive monthsEpisodesDisabilityScreening Mammography: Is It Suitably Targeted to Older Women Who are Most Likely to Benefit?
Scinto J, Gill T, Grady J, Holmboe E. Screening Mammography: Is It Suitably Targeted to Older Women Who are Most Likely to Benefit? Journal Of The American Geriatrics Society 2001, 49: 1101-1104. PMID: 11555074, DOI: 10.1046/j.1532-5415.2001.49216.x.Peer-Reviewed Original ResearchConceptsOlder womenPrognostic groupsPrognostic stageMammography useCommunity-dwelling older womenFavorable prognostic groupFive-year mortalityProspective cohort studyWorst prognostic groupMammography use ratesCause mortalityCohort studyElderly ProgramEpidemiologic studiesNew Haven CountyMedicare Part BScreening mammographyWomenMortalityMortality indexMammographyUse ratesNew HavenMammogramsPart B
2000
Environmental Hazards and the Risk of Nonsyncopal Falls in the Homes of Community-Living Older Persons
Gill T, Williams C, Tinetti M. Environmental Hazards and the Risk of Nonsyncopal Falls in the Homes of Community-Living Older Persons. Medical Care 2000, 38: 1174-1183. PMID: 11186296, DOI: 10.1097/00005650-200012000-00004.Peer-Reviewed Original ResearchConceptsNonsyncopal fallsOlder personsCommunity-living older personsProspective cohort studyBalance/gaitYears of ageFall calendarsCohort studyResearch nursesRoom assessmentFall preventionRelative riskSlip hazardsConsistent associationNumber of participantsRiskFace validityPhone callsHigh face validityProbability sampleAgeAssociationFallYearsStandard instrumentsHealth, Functional, and Psychological Outcomes Among Older Persons with Chronic Dizziness
Tinetti M, Williams C, Gill T. Health, Functional, and Psychological Outcomes Among Older Persons with Chronic Dizziness. Journal Of The American Geriatrics Society 2000, 48: 417-421. PMID: 10798469, DOI: 10.1111/j.1532-5415.2000.tb04700.x.Peer-Reviewed Original ResearchConceptsSelf-rated healthChronic dizzinessDepressive symptomsInstrumental activitiesDaily livingOlder personsProspective cohort studyGoals of carePotential confounding factorsCohort studyAdverse outcomesDizzinessAge 72Clinical strategiesBaseline levelsConfounding factorsSocial disabilityDiscrete diseaseSymptomsHealth conditionsMarginal significanceHospitalizationSyncopeOutcomesPsychological outcomes
1997
Predictors of Recovery in Activities of Daily Living Among Disabled Older Persons Living in the Community
Gill T, Robison J, Tinetti M. Predictors of Recovery in Activities of Daily Living Among Disabled Older Persons Living in the Community. Journal Of General Internal Medicine 1997, 12: 757-762. PMID: 9436895, PMCID: PMC1497202, DOI: 10.1046/j.1525-1497.1997.07161.x.Peer-Reviewed Original ResearchConceptsGood nutritional statusADL functionDisabled older personsNutritional statusADL recoveryDaily livingFolstein Mini-Mental State Examination (MMSE) scoresOlder personsMini-Mental State Examination scoreMarkers of resiliencyProspective cohort studyPredictors of recoveryState Examination scoreIntact cognitive functionCohort studyMultivariable analysisMore ADLsMMSE scoresSelf-efficacy scoresHome assessmentBivariate analysisCognitive functionGeneral communityPhysical performanceADL