1999
Clinical and Neurobiological Correlates of Cytogenetic Abnormalities in Childhood-Onset Schizophrenia
Nicolson R, Giedd JN, Lenane M, Hamburger S, Singaracharlu S, Bedwell J, Fernandez T, Thaker GK, Malaspina D, Rapoport JL. Clinical and Neurobiological Correlates of Cytogenetic Abnormalities in Childhood-Onset Schizophrenia. American Journal Of Psychiatry 1999, 156: 1575-1579. PMID: 10518169, DOI: 10.1176/ajp.156.10.1575.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetBrainBrief Psychiatric Rating ScaleCerebral VentriclesChildChromosome AberrationsChromosome DeletionDevelopmental DisabilitiesFamilyFemaleHippocampusHumansIntelligence TestsMagnetic Resonance ImagingMalePrevalencePsychiatric Status Rating ScalesRisk FactorsSchizophreniaSchizophrenic PsychologyConceptsChildhood-onset schizophreniaCytogenetic abnormalitiesCytogenetic anomaliesEye tracking dysfunctionSubgroup of patientsChromosome 22q11 deletionNeurobiological correlatesRisk factor measuresSchizophrenia spectrum disordersObstetric complicationsGroup of childrenEtiologic contributionPathophysiologic roleChildhood onsetFragile X testingLower performance IQPatientsGreater impairmentAbnormalitiesDevelopmental impairmentEarly onsetChromosomal abnormalitiesSchizophreniaEarly ageImpairment
1998
Brief Report: Association of Sex Chromosome Anomalies With Childhood-Onset Psychotic Disorders
KUMRA S, WIGGS E, KRASNEWICH D, MECK J, SMITH A, BEDWELL J, FERNANDEZ T, JACOBSEN L, LENANE M, RAPOPORT J. Brief Report: Association of Sex Chromosome Anomalies With Childhood-Onset Psychotic Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 292-296. PMID: 9519634, DOI: 10.1097/00004583-199803000-00014.Peer-Reviewed Original ResearchConceptsChildhood-onset schizophreniaPsychotic disordersPediatric patientsSex chromosome anomaliesSubgroup of patientsAdult-onset schizophreniaChromosome anomaliesLoss of balanceUnspecified psychosisTreatment trialsGeneral populationPatientsSex chromosome aneuploidyMental healthDisordersNational InstituteAffected individualsEnvironmental insultsCytogenetic screeningSchizophreniaChromosome aneuploidyChildrenClozapinePsychosisInsult