2024
Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-life
2023
Passive transfer of alloantibodies through breast milk as a mediator of hemolytic anemia
Abels E, Jacobs J, Prior D, Willets L, Sostin N, Tormey C, Binns T. Passive transfer of alloantibodies through breast milk as a mediator of hemolytic anemia. Transfusion 2023, 63: 2188-2196. PMID: 37706556, DOI: 10.1111/trf.17548.Peer-Reviewed Original ResearchConceptsMaternal breast milkBreast milkNeonatal circulationRed blood cellsPassive transferAntiviral IgG antibodiesResolution of anemiaPaucity of dataNeonatal red blood cellsIntravenous immunoglobulinMaternal alloantibodiesMaternal antibodiesPlacental transferRBC antibodiesIgG antibodiesHemolytic diseaseHemolytic anemiaPlasma titersAlloantibodiesHDFNBlood cellsAntibodiesSignificant decreasePatientsAnemiaWarm autoantibodies mimicking alloantibodies: Three cases of autoantibodies with unusual antigenic specificity
Jacobs J, Binns T, Abels E, Campos J, Elkabbani R, Kress A, Sostin N, Tormey C. Warm autoantibodies mimicking alloantibodies: Three cases of autoantibodies with unusual antigenic specificity. American Journal Of Clinical Pathology 2023, 160: 561-565. PMID: 37598315, DOI: 10.1093/ajcp/aqad095.Peer-Reviewed Original ResearchConceptsWarm autoantibodiesRed blood cellsAntigenic specificityCase of autoantibodiesCase 1Autoimmune hemolytic anemiaDirect antiglobulin testRBC transfusionPregnant womenTransfusion reactionsAntiglobulin testHemolytic anemiaAutoantibodiesRBC antigensAntibody detectionRBC unitsRare reportsBlood cellsCase 2Immunohematologic testingSignificant hemolysisRhD typingCase 3AlloantibodiesAutoantiEpidemiological and clinical features, therapeutic strategies and outcomes in patients with hyperhaemolysis: A systematic review
Jacobs J, Stephens L, Allen E, Binns T, Booth G, Hendrickson J, Karafin M, Tormey C, Woo J, Adkins B. Epidemiological and clinical features, therapeutic strategies and outcomes in patients with hyperhaemolysis: A systematic review. British Journal Of Haematology 2023, 201: 1025-1032. PMID: 37074146, DOI: 10.1111/bjh.18825.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSickle cell diseaseHyperhaemolysis syndromeAnti-globulin testRed blood cellsSupportive transfusionsIndirect anti-globulin testDirect anti-globulin testIntravenous immune globulinHaemolytic transfusion reactionsImmune globulinMedian hemoglobinClinical featuresCommon therapyUnderlying pathophysiologyTransfusion reactionsCell diseaseSevere formTherapeutic strategiesPatientsSystematic reviewBlood cellsTransfusionHyperhaemolysisDaysCorticosteroidsHemolytic disease of the fetus and newborn mediated by anti-Dia in a U.S. hospital
Jacobs J, Abels E, Binns T, Tormey C, Sostin N. Hemolytic disease of the fetus and newborn mediated by anti-Dia in a U.S. hospital. Immunohematology 2023, 39: 32-34. PMID: 37017601, DOI: 10.21307/immunohematology-2023-006.Peer-Reviewed Case Reports and Technical NotesConceptsHemolytic diseaseCases of HDFNU.S. hospitalsHemolytic transfusion reactionsDirect antiglobulin testNeonatal bilirubin levelsSouth American descentAntibody detection testsLow-prevalence antigensU.S. patient populationNear universal absenceHDFN casesBilirubin levelsPatient populationTransfusion reactionsAntiglobulin testUnexpected causeHispanic ethnicityBlood group systemAntigenAntibodiesHDFNHospitalFetusesDiseaseRh alloimmunization following transfusion of one apheresis platelet unit
Abels E, Binns T, Jacobs J, Stendahl K, Tormey C. Rh alloimmunization following transfusion of one apheresis platelet unit. Transfusion 2023, 63: 656-657. PMID: 36939478, DOI: 10.1111/trf.17258.Peer-Reviewed Case Reports and Technical NotesAutoimmune haemolytic anaemia secondary to babesiosis: A review of reported cases and description of a novel association with cold antibody‐mediated haemolytic anaemia
Jacobs J, Binns T, Abels E, Tormey C. Autoimmune haemolytic anaemia secondary to babesiosis: A review of reported cases and description of a novel association with cold antibody‐mediated haemolytic anaemia. British Journal Of Haematology 2023, 201: 364-369. PMID: 36808377, DOI: 10.1111/bjh.18710.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsWarm autoimmune hemolytic anemia with anti‐Jka specificity following babesiosis masquerading as a delayed hemolytic transfusion reaction
Jacobs J, Abels E, Binns T, Tormey C, Sostin N. Warm autoimmune hemolytic anemia with anti‐Jka specificity following babesiosis masquerading as a delayed hemolytic transfusion reaction. Transfusion 2023, 63: 872-876. PMID: 36648131, DOI: 10.1111/trf.17252.Peer-Reviewed Case Reports and Technical NotesConceptsWarm autoimmune hemolytic anemiaDirect antiglobulin testAutoimmune hemolytic anemiaHemolytic transfusion reactionsRed blood cellsRBC transfusionTransfusion reactionsHemolytic anemiaKidd antigensPositive direct antiglobulin testDevelopment of autoantibodiesBabesia microti infectionImmunohematology reference laboratoryColumn agglutination technologyAnti-JkUndetectable parasitemiaAutoantibody statusWarm autoantibodiesRBC antibodiesMicroti infectionAntiglobulin testAntigen specificityAutoantibodiesHealthcare providersAntibody detection
2022
State of the Evidence: Drug Removal via Apheresis
Binns T, Sostin N, Tormey C. State of the Evidence: Drug Removal via Apheresis. Transfusion Medicine Reviews 2022, 37: 16-20. PMID: 36604194, DOI: 10.1016/j.tmrv.2022.12.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAlloimmunization following antigen‐negative red blood cell transfusion
Jacobs J, Binns T, Abels E, Iyer K, Villalba C, Verma A, Sostin N, Tormey C. Alloimmunization following antigen‐negative red blood cell transfusion. Transfusion 2022, 63: 430-434. PMID: 36458330, DOI: 10.1111/trf.17208.Peer-Reviewed Case Reports and Technical NotesConceptsTransfusion of RBCsRed blood cell transfusionRed blood cell alloimmunizationPrevious antigen exposureBlood cell transfusionAlloantibody specificitiesCell transfusionRBC transfusionAntigen exposureRBC alloantibodiesAntigenic stimulusDetectable titersAntigenic stimulationMyeloid neoplasmsTransfusionAlloantibodiesAlloimmunizationParticular antigenPrior exposureStimulatory eventsExact mechanismCorresponding antibodiesRBCsExposurePregnancy
2021
CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy
Binns TC, Koch CD, Durant TJS, El-Khoury JM. CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy. The Journal Of Applied Laboratory Medicine 2021, 6: 1671-1676. PMID: 34383919, DOI: 10.1093/jalm/jfab071.Peer-Reviewed Case Reports and Technical Notes
2020
Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems
Binns TC, Ayala AX, Grimm JB, Tkachuk AN, Castillon GA, Phan S, Zhang L, Brown TA, Liu Z, Adams SR, Ellisman MH, Koyama M, Lavis LD. Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems. Cell Chemical Biology 2020, 27: 1063-1072.e7. PMID: 32698018, PMCID: PMC7483975, DOI: 10.1016/j.chembiol.2020.07.001.Peer-Reviewed Original ResearchConceptsBiological systemsChemical toolsRational designChemical reactionsPhotosensitizerElectron microscopyChromophore-assisted light inactivationNumerous biological experimentsHigh-resolution imagingPowerful methodPhotopolymerizationReactive oxygen speciesRhodamineOxygen speciesSynthesisTargeted destructionReactionBiological experimentsBroad rangeMicroscopyCharacterizationCell ablationDiaminobenzidine