2016
The transmission of Mycobacterium tuberculosis in high burden settings
Yates TA, Khan PY, Knight GM, Taylor JG, McHugh TD, Lipman M, White RG, Cohen T, Cobelens FG, Wood R, Moore DA, Abubakar I. The transmission of Mycobacterium tuberculosis in high burden settings. The Lancet Infectious Diseases 2016, 16: 227-238. PMID: 26867464, DOI: 10.1016/s1473-3099(15)00499-5.Peer-Reviewed Original ResearchConceptsHigh-burden settingsBurden settingsTuberculosis infection controlMycobacterium tuberculosis transmissionEffects of HIVHealth care workersDrug-resistant strainsAntiretroviral therapyPerson transmissionTuberculosis transmissionInfection controlTransmission riskAirborne transmissionMycobacterium tuberculosisWells-Riley equationPresent research prioritiesTransmission dynamicsResearch prioritiesHIVEffective strategyTherapyTuberculosisSettingTrials
2013
Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis
Mills HL, Cohen T, Colijn C. Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis. Science Translational Medicine 2013, 5: 180ra49. PMID: 23576815, PMCID: PMC3714172, DOI: 10.1126/scitranslmed.3005260.Peer-Reviewed Original ResearchConceptsDrug-resistant TBIPT interventionDrug-sensitive infectionsIsoniazid-resistant TBHIV/TBRisk of progressionHigh HIV prevalenceDrug-resistant diseaseIsoniazid-resistant Mycobacterium tuberculosisSymptom-free individualsSignificant elevated riskDrug-resistant strainsWorld Health OrganizationActive TBTB controlResistant tuberculosisHIV prevalenceTuberculosis controlIPT programElevated riskHost immunityMycobacterium tuberculosisHealth OrganizationSelective suppressionInterventionBayesian Estimation of Mixture Models with Prespecified Elements to Compare Drug Resistance in Treatment-Naïve and Experienced Tuberculosis Cases
Izu A, Cohen T, DeGruttola V. Bayesian Estimation of Mixture Models with Prespecified Elements to Compare Drug Resistance in Treatment-Naïve and Experienced Tuberculosis Cases. PLOS Computational Biology 2013, 9: e1002973. PMID: 23555210, PMCID: PMC3605089, DOI: 10.1371/journal.pcbi.1002973.Peer-Reviewed Original ResearchConceptsTreatment-experienced patientsDrug-resistant strainsMultiple drug-resistant strainsTreatment-naïve patientsDrug-resistant tuberculosisMycobacterium tuberculosis isolatesWorld Health OrganizationDrug resistance pathwaysTreatment-naïveTuberculosis casesTuberculosis isolatesWorldwide surveillanceDrug resistancePatientsHealth OrganizationResistant strainsResistant pathogensResistance pathwaysLow transmissibilityPathwayTuberculosis
2011
Models to understand the population-level impact of mixed strain M. tuberculosis infections
Sergeev R, Colijn C, Cohen T. Models to understand the population-level impact of mixed strain M. tuberculosis infections. Journal Of Theoretical Biology 2011, 280: 88-100. PMID: 21514304, PMCID: PMC3111980, DOI: 10.1016/j.jtbi.2011.04.011.Peer-Reviewed Original ResearchConceptsDrug-resistant strainsMixed strain infectionsStrain infectionDrug-sensitive tuberculosisDrug-resistant tuberculosisM. tuberculosis infectionLower basic reproductive numberDrug-resistant infectionsTuberculosis patientsTuberculosis infectionTreatment successDrug-resistant bacteriaFuture burdenLong-term effectsStrain-specific differencesDrug resistanceInfectionPopulation-level impactTuberculosisM. tuberculosisMixed infectionsMycobacterium tuberculosisBasic reproductive numberCo-infected hostsSmall subpopulation
2009
What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?
Colijn C, Cohen T, Fraser C, Hanage W, Goldstein E, Givon-Lavi N, Dagan R, Lipsitch M. What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae? Journal Of The Royal Society Interface 2009, 7: 905-919. PMID: 19940002, PMCID: PMC2871802, DOI: 10.1098/rsif.2009.0400.Peer-Reviewed Original ResearchConceptsDrug-resistant strainsStreptococcus pneumoniaeInfectious diseasesDrug-susceptible strainsHigher reproduction numberCent prevalenceSubstantial prevalencePersistent coexistenceDrug resistanceMultiple infectionsAntimicrobial useResistant strainsBacterial spreadAntimicrobial resistancePrevalenceDiseasePneumoniaeOutcomesReproduction numberTreatmentHost interactionsPathogensCoinfection
2008
Latent Coinfection and the Maintenance of Strain Diversity
Colijn C, Cohen T, Murray M. Latent Coinfection and the Maintenance of Strain Diversity. Bulletin Of Mathematical Biology 2008, 71: 247. PMID: 19082663, PMCID: PMC2652765, DOI: 10.1007/s11538-008-9361-y.Peer-Reviewed Original ResearchAre Survey-Based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study
Cohen T, Colijn C, Finklea B, Wright A, Zignol M, Pym A, Murray M. Are Survey-Based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study. PLOS ONE 2008, 3: e2363. PMID: 18523659, PMCID: PMC2408555, DOI: 10.1371/journal.pone.0002363.Peer-Reviewed Original ResearchConceptsResistant tuberculosisIncident casesTotal burdenDrug-resistant TBDrug-resistant tuberculosisSecond-line antibioticsDrug treatment regimensDrug sensitivity testingDrug-resistant strainsBurden of resistanceEmergence of tuberculosisResistant TBTreatment regimensPrevalent casesWorldwide burdenIntroduction of interventionsRoutine surveillanceSurveillance strategiesDrug resistanceTuberculosisLaboratory capacityMycobacterium tuberculosisSensitivity testingTuberculosis modelBurden