2018
Elevated Thrombospondin‐2 Contributes to Delayed Wound Healing in Diabetes
Kunkemoeller B, Kyriakides T. Elevated Thrombospondin‐2 Contributes to Delayed Wound Healing in Diabetes. The FASEB Journal 2018, 32: 414.3-414.3. DOI: 10.1096/fasebj.2018.32.1_supplement.414.3.Peer-Reviewed Original ResearchKO mice exhibitThrombospondin-2TSP2 expressionDiabetes patientsImpaired healingMouse modelWound healingMice exhibitDb/db miceWild-type miceKO mouse modelUnderlying pathological mechanismsImpaired wound healingDelayed Wound HealingFull-text articlesMajor complicationsDiabetes complicationsDb miceKO miceTreatment strategiesTissue injuryDiabetesPathological mechanismsDiabetic woundsChronic wounds
2000
Thrombospondin 2, a matricellular protein with diverse functions
Bornstein P, Armstrong L, Hankenson K, Kyriakides T, Yang Z. Thrombospondin 2, a matricellular protein with diverse functions. Matrix Biology 2000, 19: 557-568. PMID: 11102746, DOI: 10.1016/s0945-053x(00)00104-9.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-2TSP2-null miceThrombospondin-2Matricellular proteinConnective tissueGrowth of tumorsConnective tissue elementsFragility of skinFunctional abnormalitiesTissue injuryMetalloproteinase-2MMP2 activityBleeding defectMiceCell surface receptorsGrowth factorAdult animalsMode of actionBone growthMarked disparityTissue elementsSubdermal tissueAbnormalitiesDermal fibroblastsTissue