2007
Thrombospondin 2 deficiency influences extracellular matrix assembly leading to increased ischemia‐induced angiogenesis and arteriogenesis
Kyriakides T, Krady M, Zeng J, Skokos E. Thrombospondin 2 deficiency influences extracellular matrix assembly leading to increased ischemia‐induced angiogenesis and arteriogenesis. The FASEB Journal 2007, 21: a529-a529. DOI: 10.1096/fasebj.21.5.a529-a.Peer-Reviewed Original Research
2004
The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation
Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ, Bornstein P. The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation. American Journal Of Pathology 2004, 165: 2157-2166. PMID: 15579457, PMCID: PMC1618731, DOI: 10.1016/s0002-9440(10)63265-8.Peer-Reviewed Original ResearchConceptsForeign body giant cellsForeign body reactionCC chemokine ligand 2CCL2-null miceChemokine ligand 2CC chemokine ligandBlood-borne monocytesPeripheral blood monocytesWild-type miceCCL2/MCP1Chemokine ligandGiant cell formationMonocyte recruitmentBlood monocytesFBGC formationMacrophage fusionGiant cellsImplantation sitesBody reactionForeign body giant cell formationMiceInhibitory peptidesCCL2 functionMonocytesChemotactic signals
2001
Altered Extracellular Matrix Remodeling and Angiogenesis in Sponge Granulomas of Thrombospondin 2-Null Mice
Kyriakides T, Zhu Y, Yang Z, Huynh G, Bornstein P. Altered Extracellular Matrix Remodeling and Angiogenesis in Sponge Granulomas of Thrombospondin 2-Null Mice. American Journal Of Pathology 2001, 159: 1255-1262. PMID: 11583953, PMCID: PMC1850515, DOI: 10.1016/s0002-9440(10)62512-6.Peer-Reviewed Original ResearchConceptsTSP2-null miceMatrix remodelingWild-type miceMatrix metalloproteinase-2Wild-type animalsExtracellular matrix remodelingModulators of angiogenesisFibrogenic responseImmunohistochemical analysisMetalloproteinase-2Minimal scarringMMP2 levelsSponge granulomaAngiogenesis inhibitorsMice displayVivo evidenceThrombospondin-2MiceGrowth factorImportant modulatorTissue invasionTSP2-nullWound healingAngiogenesisSignificant differences
2000
Thrombospondin 2, a matricellular protein with diverse functions
Bornstein P, Armstrong L, Hankenson K, Kyriakides T, Yang Z. Thrombospondin 2, a matricellular protein with diverse functions. Matrix Biology 2000, 19: 557-568. PMID: 11102746, DOI: 10.1016/s0945-053x(00)00104-9.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-2TSP2-null miceThrombospondin-2Matricellular proteinConnective tissueGrowth of tumorsConnective tissue elementsFragility of skinFunctional abnormalitiesTissue injuryMetalloproteinase-2MMP2 activityBleeding defectMiceCell surface receptorsGrowth factorAdult animalsMode of actionBone growthMarked disparityTissue elementsSubdermal tissueAbnormalitiesDermal fibroblastsTissueThrombospondin 2 Modulates Collagen Fibrillogenesis and Angiogenesis
Bornstein P, Kyriakides T, Yang Z, Armstrong L, Birk D. Thrombospondin 2 Modulates Collagen Fibrillogenesis and Angiogenesis. Journal Of Investigative Dermatology Symposium Proceedings 2000, 5: 61-66. PMID: 11147677, DOI: 10.1046/j.1087-0024.2000.00005.x.Peer-Reviewed Original ResearchConceptsVascular densityTSP2-null miceMatrix metalloproteinase-2 productionMetalloproteinase-2 productionConnective tissue abnormalitiesFlexor muscle tendonsExcisional skin woundsPolyvinyl alcohol spongesSilicone rubber discsAbnormal collagen fibrilsMuscle tendonSubcutaneous tissueNull miceTissue abnormalitiesDistinct abnormalitiesEndothelial cellsThrombospondin-2Matricellular proteinAlcohol spongesTHBS2 geneCell functionCell-matrix interactionsMiceSkin woundsMode of actionIncreased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2*
Hankenson K, Bain S, Kyriakides T, Smith E, Goldstein S, Bornstein P. Increased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2*. Journal Of Bone And Mineral Research 2000, 15: 851-862. PMID: 10804014, DOI: 10.1359/jbmr.2000.15.5.851.Peer-Reviewed Original ResearchConceptsBone formation rateEndosteal bone formation rateEndosteal bone formationTSP2-null miceMarrow stromal cellsComputerized tomographyThrombospondin-2Bone formationNormal bone resorptionWild-type animalsOvariectomized miceBone lossCortical densityRate of proliferationBone resorptionLigamentous laxityBone massVascular densityHistomorphometric analysisNull miceMutant miceStromal cellsMiceLong bonesCellular basis
1999
Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene
Kyriakides T, Tam J, Bornstein P. Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene. Journal Of Investigative Dermatology 1999, 113: 782-787. PMID: 10571734, DOI: 10.1046/j.1523-1747.1999.00755.x.Peer-Reviewed Original ResearchConceptsGranulation tissueThrombospondin-2Late woundsControl woundsWound healingExtent of angiogenesisRe-epithelization rateAbnormal collagen fibrilsVascular densityLess scarringRete pegsHistologic analysisExcisional woundsControl epitheliumSuch woundsThrombospondin 2 geneTotal cellular contentAccelerated wound healingElevated levelsHealing processMiceWoundsBiopsy punchEarly woundsHealing