2022
Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity
Kyriakides TR, Kim HJ, Zheng C, Harkins L, Tao W, Deschenes E. Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity. Biomedical Materials 2022, 17: 022007. PMID: 35168213, PMCID: PMC9159526, DOI: 10.1088/1748-605x/ac5574.Peer-Reviewed Original ResearchConceptsAdaptive immune cellsForeign body reactionImmune cellsAdaptive immunityImmune-inflammatory cellsSpecific macrophage subsetsSpecific antibody responseForeign body giant cellsWound repair cellsInflammatory cellsAntibody responseFavorable outcomeMacrophage subtypesDistinct immuneMacrophage subsetsB cellsGiant cellsRegenerative responseBody reactionRepair cellsImmunityForeign body responseExact participationBody responseContradictory studies
2016
Nanoparticle delivery of miR-223 to attenuate macrophage fusion
Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR. Nanoparticle delivery of miR-223 to attenuate macrophage fusion. Biomaterials 2016, 89: 127-135. PMID: 26967647, PMCID: PMC4924476, DOI: 10.1016/j.biomaterials.2016.02.036.Peer-Reviewed Original ResearchConceptsForeign body giant cellsMiR-223 mimicsMiR-223Foreign body responseMacrophage fusionSubsequent cytoskeletal rearrangementMiR microarrayKO miceRole of microRNAsMolecular mediatorsNegative regulatorGiant cellsPrimary macrophagesFusion of macrophagesNovel mediatorPrecise mechanismFusion-competent stateTherapeutic inhibitorsBody responseMacrophagesNanoparticle deliveryImplant modelMediatorsEventual encapsulationPost-transcriptional level
2004
The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation
Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ, Bornstein P. The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation. American Journal Of Pathology 2004, 165: 2157-2166. PMID: 15579457, PMCID: PMC1618731, DOI: 10.1016/s0002-9440(10)63265-8.Peer-Reviewed Original ResearchConceptsForeign body giant cellsForeign body reactionCC chemokine ligand 2CCL2-null miceChemokine ligand 2CC chemokine ligandBlood-borne monocytesPeripheral blood monocytesWild-type miceCCL2/MCP1Chemokine ligandGiant cell formationMonocyte recruitmentBlood monocytesFBGC formationMacrophage fusionGiant cellsImplantation sitesBody reactionForeign body giant cell formationMiceInhibitory peptidesCCL2 functionMonocytesChemotactic signals