2022
Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity
Kyriakides TR, Kim HJ, Zheng C, Harkins L, Tao W, Deschenes E. Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity. Biomedical Materials 2022, 17: 022007. PMID: 35168213, PMCID: PMC9159526, DOI: 10.1088/1748-605x/ac5574.Peer-Reviewed Original ResearchConceptsAdaptive immune cellsForeign body reactionImmune cellsAdaptive immunityImmune-inflammatory cellsSpecific macrophage subsetsSpecific antibody responseForeign body giant cellsWound repair cellsInflammatory cellsAntibody responseFavorable outcomeMacrophage subtypesDistinct immuneMacrophage subsetsB cellsGiant cellsRegenerative responseBody reactionRepair cellsImmunityForeign body responseExact participationBody responseContradictory studies
2004
The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation
Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ, Bornstein P. The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation. American Journal Of Pathology 2004, 165: 2157-2166. PMID: 15579457, PMCID: PMC1618731, DOI: 10.1016/s0002-9440(10)63265-8.Peer-Reviewed Original ResearchConceptsForeign body giant cellsForeign body reactionCC chemokine ligand 2CCL2-null miceChemokine ligand 2CC chemokine ligandBlood-borne monocytesPeripheral blood monocytesWild-type miceCCL2/MCP1Chemokine ligandGiant cell formationMonocyte recruitmentBlood monocytesFBGC formationMacrophage fusionGiant cellsImplantation sitesBody reactionForeign body giant cell formationMiceInhibitory peptidesCCL2 functionMonocytesChemotactic signals