2022
Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity
Kyriakides TR, Kim HJ, Zheng C, Harkins L, Tao W, Deschenes E. Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity. Biomedical Materials 2022, 17: 022007. PMID: 35168213, PMCID: PMC9159526, DOI: 10.1088/1748-605x/ac5574.Peer-Reviewed Original ResearchConceptsAdaptive immune cellsForeign body reactionImmune cellsAdaptive immunityImmune-inflammatory cellsSpecific macrophage subsetsSpecific antibody responseForeign body giant cellsWound repair cellsInflammatory cellsAntibody responseFavorable outcomeMacrophage subtypesDistinct immuneMacrophage subsetsB cellsGiant cellsRegenerative responseBody reactionRepair cellsImmunityForeign body responseExact participationBody responseContradictory studies
2017
The host response to naturally-derived extracellular matrix biomaterials
Morris AH, Stamer DK, Kyriakides TR. The host response to naturally-derived extracellular matrix biomaterials. Seminars In Immunology 2017, 29: 72-91. PMID: 28274693, DOI: 10.1016/j.smim.2017.01.002.Peer-Reviewed Original Research
2016
Nanoparticle delivery of miR-223 to attenuate macrophage fusion
Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR. Nanoparticle delivery of miR-223 to attenuate macrophage fusion. Biomaterials 2016, 89: 127-135. PMID: 26967647, PMCID: PMC4924476, DOI: 10.1016/j.biomaterials.2016.02.036.Peer-Reviewed Original ResearchConceptsForeign body giant cellsMiR-223 mimicsMiR-223Foreign body responseMacrophage fusionSubsequent cytoskeletal rearrangementMiR microarrayKO miceRole of microRNAsMolecular mediatorsNegative regulatorGiant cellsPrimary macrophagesFusion of macrophagesNovel mediatorPrecise mechanismFusion-competent stateTherapeutic inhibitorsBody responseMacrophagesNanoparticle deliveryImplant modelMediatorsEventual encapsulationPost-transcriptional level
2011
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response
Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 20095-20100. PMID: 22109549, PMCID: PMC3250158, DOI: 10.1073/pnas.1105152108.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsApoptosis Regulatory ProteinsAspirinBiocompatible MaterialsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCarrier ProteinsCaspase 1Cluster AnalysisCytoskeletal ProteinsForeign-Body ReactionGiant CellsInflammasomesInflammationInterleukin-1betaMacrophages, PeritonealMembrane MicrodomainsMiceMice, Inbred C57BLMicrospheresNLR Family, Pyrin Domain-Containing 3 ProteinPolymethyl Methacrylate
2009
Bulk metallic glasses for biomedical applications
Schroers J, Kumar G, Hodges T, Chan S, Kyriakides T. Bulk metallic glasses for biomedical applications. JOM 2009, 61: 21-29. DOI: 10.1007/s11837-009-0128-1.Peer-Reviewed Original ResearchBulk metallic glassMetallic glassesBiomedical applicationsField of biomaterialsMetallic biomaterialsImplant applicationsExcellent combinationMaterial propertiesSuperior propertiesComplex implantsSurface topographyDesirable biological responsesForeign body responseBiomaterialsProcessing capabilitiesFlexible chemistryGlassPropertiesAtomic structureApplicationsBiocompatibilityBody responseDevicesMaterials