Problem drinking and the interaction of reward, negative emotion, and cognitive control circuits during cue-elicited craving
Le T, Chen Y, Chaudhary S, Li C. Problem drinking and the interaction of reward, negative emotion, and cognitive control circuits during cue-elicited craving. Addiction Neuroscience 2022, 1: 100004. DOI: 10.1016/j.addicn.2021.100004.Peer-Reviewed Original ResearchCognitive control circuitsPositive alcohol expectanciesNegative emotionsAlcohol use severityCognitive controlMotivational processesCue exposureAlcohol expectanciesUse severityAlcohol useAlcohol cue exposureCue-elicited cravingSocial isolationIndividual differencesReward responsesNegative reinforcementAdult drinkersEmotionsPath modelProblem drinkingActivity differencesRewardDrinking behaviorCravingControl processPositive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking
Le TM, Malone T, Li CR. Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking. Drug And Alcohol Dependence 2022, 231: 109248. PMID: 34998254, PMCID: PMC8881788, DOI: 10.1016/j.drugalcdep.2021.109248.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPositive alcohol expectanciesAlcohol expectanciesInsular connectivityFunctional connectivityWhole-brain multiple regressionPath analysisNegative emotion processingVentromedial prefrontal cortexSuperior parietal lobuleSuperior frontal gyrusCognitive controlAlcohol stimuliEmotion processingPrefrontal structuresStimulus saliencyFrontal gyrusDrinking motivationsMotivational circuitsInsula connectivityParietal lobuleAdult drinkersPrefrontal cortexInsulaDrinking behavior