Featured Publications
The telomere maintenance mechanism spectrum and its dynamics in gliomas
Kim S, Chowdhury T, Yu H, Kahng J, Lee C, Choi S, Kim K, Kang H, Lee J, Lee S, Won J, Kim K, Kim M, Lee J, Kim J, Kim Y, Kim T, Choi S, Phi J, Shin Y, Ku J, Lee S, Yun H, Lee H, Kim D, Kim K, Hur J, Park S, Kim S, Park C. The telomere maintenance mechanism spectrum and its dynamics in gliomas. Genome Medicine 2022, 14: 88. PMID: 35953846, PMCID: PMC9367055, DOI: 10.1186/s13073-022-01095-x.Peer-Reviewed Original ResearchConceptsTERT promoter mutationsTelomere maintenance mechanismTelomerase activityGlioma samplesTERT expressionPromoter mutationsCancer management strategiesSlow growth potentialCancer cell immortalityC-circle assayGlioma patientsSeparate cohortNegative groupGlioma progressionNanoString analysisTumor tissueTelomerase enzyme activityGliomasTumor cellsConclusionsThis studyALTATRX mutationsTelomerase activationATRX lossConsiderable proportion
2022
Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas
Hwang T, Kim S, Chowdhury T, Yu H, Kim K, Kang H, Won J, Park S, Shin J, Park C. Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas. Communications Biology 2022, 5: 62. PMID: 35042936, PMCID: PMC8766575, DOI: 10.1038/s42003-022-03011-w.Peer-Reviewed Original ResearchConceptsCircular RNA levelsI editingGenome-wide perturbationsPost-transcriptional processesPost-transcriptional regulationRNA expressionRNA levelsAlu expressionHuman genomeRNA-seqRegulatory elementsRepeat elementsGenetic elementsAlu subfamiliesBiological processesGrade 2 oligodendrogliomaAluExpressionGliomagenesisEditingUnique patternTranscriptomeGenomeSubfamiliesNormal tissuesSpatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma
Kim A, Choi S, Park J, Kwon M, Chowdhury T, Yu H, Kim S, Kang H, Kim K, Park S, Park C, Shin E. Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma. OncoImmunology 2022, 11: 2026019. PMID: 35036078, PMCID: PMC8757477, DOI: 10.1080/2162402x.2022.2026019.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasTumor immune microenvironmentTumor-associated macrophagesM2 tumor-associated macrophagesT cellsExhausted CD8Immune cellsImmunosuppressive cellsCTLA-4Hypoxic conditionsImmunosuppressive tumor immune microenvironmentProgression-free survivalRegulatory T cellsSurvival of patientsImmunosuppressive profilePD-1Patient survivalImmune microenvironmentImmune heterogeneityHypoxia signatureCD8Different biological featuresPatientsFlow cytometrySurvival
2021
Absolute quantification of tumor-infiltrating immune cells in high-grade glioma identifies prognostic and radiomics values
Kim A, Choi K, Kim M, Kim K, Kang H, Kim S, Chowdhury T, Yu H, Lee C, Lee J, Lee S, Won J, Kim J, Kim Y, Kim T, Park S, Choi S, Shin E, Park C. Absolute quantification of tumor-infiltrating immune cells in high-grade glioma identifies prognostic and radiomics values. Cancer Immunology, Immunotherapy 2021, 70: 1995-2008. PMID: 33416947, PMCID: PMC10991432, DOI: 10.1007/s00262-020-02836-w.Peer-Reviewed Original ResearchConceptsTumor-infiltrating immune cellsHigh-grade gliomasImmune cellsTumor-associated macrophagesImmune microenvironmentRadiomics signatureClinical prognostic relevanceImmune cell numbersImmune cell subpopulationsImmune microenvironment characteristicsTumor immune microenvironmentCore tissueApparent diffusion coefficient (ADC) mapsDiffusion coefficient mapsOverall survivalPrognostic impactPatient groupPrognostic relevanceClinical prognosisImmune characteristicsImmune phenotypeMedian numberM2 TAMsTumor tissueMethodsThe number