Subcellular progression of mesenchymal transition identified by two discrete synchronous cell lines derived from the same glioblastoma
Kim S, Park S, Chowdhury T, Hong J, Ahn J, Jeong T, Yu H, Shin Y, Ku J, Park J, Hur J, Lee H, Kim K, Park C. Subcellular progression of mesenchymal transition identified by two discrete synchronous cell lines derived from the same glioblastoma. Cellular And Molecular Life Sciences 2022, 79: 181. PMID: 35278143, PMCID: PMC8918182, DOI: 10.1007/s00018-022-04188-3.Peer-Reviewed Original ResearchConceptsMesenchymal transitionCell linesAvailable single-cell RNA-seq dataMesenchymal transition (EMT) processCancer cell linesSame tissue samplesTherapeutic implicationsTumor samplesRecurrent samplesDriver mutationsGlioblastomaTissue samplesDistinct cancer cell linesGBM samplesIntratumoral heterogeneityTranscriptomic characteristicsGenomic analysis of synchronous intracranial meningiomas with different histological grades
Chowdhury T, Yoo Y, Seo Y, Dho Y, Kim S, Choi A, Choi M, Park S, Park C, Lee S, Lee J. Genomic analysis of synchronous intracranial meningiomas with different histological grades. Journal Of Neuro-Oncology 2018, 138: 41-48. PMID: 29423538, DOI: 10.1007/s11060-018-2772-1.Peer-Reviewed Original ResearchConceptsDifferent histological gradesWhole-exome sequencingHistological gradeDistinct gene expression profilesRNA-seq analysisRNA sequencing analysisSynchronous meningiomaGene expression profilesYear old female patientGenomic analysisCommon primary tumorExpression profilesGenomic eventsGenomic evaluationMechanisms of progressionSubsequent mutationsHigh gradeCentral nervous system