2021
Absolute quantification of tumor-infiltrating immune cells in high-grade glioma identifies prognostic and radiomics values
Kim A, Choi K, Kim M, Kim K, Kang H, Kim S, Chowdhury T, Yu H, Lee C, Lee J, Lee S, Won J, Kim J, Kim Y, Kim T, Park S, Choi S, Shin E, Park C. Absolute quantification of tumor-infiltrating immune cells in high-grade glioma identifies prognostic and radiomics values. Cancer Immunology, Immunotherapy 2021, 70: 1995-2008. PMID: 33416947, PMCID: PMC10991432, DOI: 10.1007/s00262-020-02836-w.Peer-Reviewed Original ResearchConceptsTumor-infiltrating immune cellsHigh-grade gliomasImmune cellsTumor-associated macrophagesImmune microenvironmentRadiomics signatureClinical prognostic relevanceImmune cell numbersImmune cell subpopulationsImmune microenvironment characteristicsTumor immune microenvironmentCore tissueApparent diffusion coefficient (ADC) mapsDiffusion coefficient mapsOverall survivalPrognostic impactPatient groupPrognostic relevanceClinical prognosisImmune characteristicsImmune phenotypeMedian numberM2 TAMsTumor tissueMethodsThe number
2020
Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells
Kim S, Seo Y, Chowdhury T, Yu H, Lee C, Kim K, Kang H, Kim H, Park S, Kim K, Park C. Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells. Scientific Reports 2020, 10: 18238. PMID: 33106534, PMCID: PMC7589558, DOI: 10.1038/s41598-020-75457-z.Peer-Reviewed Original ResearchConceptsRole of MUC1Epithelial-mesenchymal transitionMucin 1Cell cycle arrestMUC1 knockdownNormal brain tissueExpression levelsGrowth factor betaTERT expression levelsGBM cell linesOverall survivalTherapeutic targetOncological processHuman gliomasBrain tissueFactor betaMesenchymal transitionPhosphorylation of RB1Diverse cancersGlioblastomaTelomere maintenance mechanismAnticancer mechanismCell proliferationCycle arrestGlioblastoma cells