Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma
Kim S, Kim J, Kim Y, Hwang T, Kim S, Xu W, Shin J, Kim J, Choi H, Kim H, Cho H, Choi A, Chowdhury T, Seo Y, Dho Y, Kim J, Kim D, Park S, Kim H, Choi S, Park S, Lee S, Park C. Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma. Scientific Reports 2017, 7: 12221. PMID: 28939850, PMCID: PMC5610329, DOI: 10.1038/s41598-017-12557-3.Peer-Reviewed Original ResearchConceptsGlutaminase 2Subsequent metabolite profilingInsufficient NADPHKey genesRNA sequencingExpression profilingGene expressionFunctional analysisGenesExpression levelsMetabolite profilingGBM tissuesFluorescence heterogeneityMetabolic mechanismsNADPH production capacityFluorescence intensityAcid fluorescenceProfilingExpressionGlioblastoma treatmentProtoporphyrin IXFluorescenceIntratumoral heterogeneityFluorescence-guided surgeryTissue