Featured Publications
Genomic analysis of synchronous intracranial meningiomas with different histological grades
Chowdhury T, Yoo Y, Seo Y, Dho Y, Kim S, Choi A, Choi M, Park S, Park C, Lee S, Lee J. Genomic analysis of synchronous intracranial meningiomas with different histological grades. Journal Of Neuro-Oncology 2018, 138: 41-48. PMID: 29423538, DOI: 10.1007/s11060-018-2772-1.Peer-Reviewed Original ResearchConceptsDifferent histological gradesWhole-exome sequencingHistological gradeDistinct gene expression profilesRNA-seq analysisRNA sequencing analysisSynchronous meningiomaGene expression profilesYear old female patientGenomic analysisCommon primary tumorExpression profilesGenomic eventsGenomic evaluationMechanisms of progressionSubsequent mutationsHigh gradeCentral nervous system
2024
Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression
Lee Y, Chowdhury T, Kim S, Yu H, Kim K, Kang H, Kim M, Kim J, Kim Y, Ji S, Hwang K, Han J, Hwang J, Yoo S, Lee K, Choe G, Won J, Park S, Lee Y, Shin J, Park C, Kim C, Kim J. Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression. Experimental & Molecular Medicine 2024, 56: 975-986. PMID: 38609519, PMCID: PMC11059271, DOI: 10.1038/s12276-024-01204-3.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingNeuronal development pathwaysDrivers of tumorigenesisGlial cell differentiationMethylation sequencingGenomic eventsPI3K-Akt activationDownstream eventsGene markersMultiomics approachCell differentiationRadial glial cellsHypomethylationOverexpressionSequenceTumorigenesisFGFR3Cell signaturesGlial cellsPotential roleCellsTumor cellsCentral nervous systemMultiomicsOntogeny